Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17
文献类型：期刊论文
| 作者 | Bechthold, Andreas1; Zhu, Jing1; Liu, Tao2; Zhang, Songya1; Samra, Suzan1; Pan, Huaqi3; Bai, Jiao4; Hua, Huiming4 |
| 刊名 | HELVETICA CHIMICA ACTA
 |
| 出版日期 | 2016-03-01 |
| 卷号 | 99期号:3页码:215-219 |
| 关键词 | Secondary Metabolites Fungi Myrothecium Glycosylated Polyketides Antibacterial Activity |
| ISSN号 | 0018-019X |
| DOI | 10.1002/hlca.201500218 |
| 英文摘要 | Based on the chemical analysis and targeted bioactivity screening, a new polyketide glycoside, myrothecoside, was isolated from a terrestrial halotolerant fungus, Myrothecium sp. GS-17. The structure of myrothecoside was elucidated on the basis of extensive spectroscopic analysis including 1D- and 2D-NMR (H-1,H-1-COSY, HSQC, HMBC, and NOESY) experiments, combined with mass spectroscopic data and physicochemical properties. This compound exhibited weak cytotoxicity against human leukemia (HL-60) cancer cell with an IG(50) value of 63.61m, and also antifungal activities against plant pathogenic fungi Rhizoctonia solani and Fusarium oxysporum using standard agar diffusion tests at 20 mu g/disk. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000373611500008 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://210.72.129.5/handle/321005/122592]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Bechthold, Andreas |
| 作者单位 | 1.Univ Freiburg, Inst Pharmazeut Biol & Biotechnol, D-79104 Freiburg, Germany 2.China Med Univ, Sch Pharm, Dept Nat Prod Chem, Shenyang 110001, Peoples R China 3.Chinese Acad Sci, Inst Appl Ecol, Shenyang 110016, Peoples R China 4.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bechthold, Andreas,Zhu, Jing,Liu, Tao,et al. Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17[J]. HELVETICA CHIMICA ACTA,2016,99(3):215-219. |
| APA | Bechthold, Andreas.,Zhu, Jing.,Liu, Tao.,Zhang, Songya.,Samra, Suzan.,...&Hua, Huiming.(2016).Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17.HELVETICA CHIMICA ACTA,99(3),215-219. |
| MLA | Bechthold, Andreas,et al."Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp GS-17".HELVETICA CHIMICA ACTA 99.3(2016):215-219. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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