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The differences in bioaccumulation and effects between Se(IV) and Se(VI) in the topmouth gudgeon Pseudorasbora parva

文献类型：期刊论文

作者Ma, Shanshan1,2; Zeng, Xiangfeng1,3; Chen, Hongxing4; Geng, Shicong5; Yan, Liang1; Luo, Yongju6; Xie, Lingtian4; Zhang, Qianru1
刊名SCIENTIFIC REPORTS
出版日期2018-09-14
卷号8页码:12
ISSN号2045-2322
DOI10.1038/s41598-018-32270-z
英文摘要Selenium (Se) might be protective against oxidative stress at nutritional levels, but elevated Se concentrations in the diet has been revealed as the main culprit for the extinction of natural fish populations in Se-contaminated lakes. Though Se predominate as waterborne selenite (IV) and selenate (VI) in the water, the differences in bioaccumulation, effects (e.g., oxidative stress, antioxidants etc.) and molecular mechanisms between Se(IV) and Se(VI) have been relatively understudied in wild fish. In this study, the P. parva were exposed to waterborne Se (10, 200 and 1000 mu g/L of Se(IV) or Se(VI)) and sampled at 4, 14 and 28 days. Bioaccumulation, tissue distributions of Se and following effects in different tissues were evaluated. The results showed that the levels of Se in the gills and intestine were significantly elevated with a seemingly concentration-dependent pattern in the Se(IV) treatment, with respectively 173.3% and 57.2% increase after 28 days of exposure, relative to that of Se(VI) treatment. Additionally, significant accumulation of Se was also observed in the muscle of Se(IV) treated fish. Se exposure increased the MDA levels in the brain and gills in the Se(IV) treatment, but less apparent in the Se(VI) treatment. Meanwhile, Se exposure lowered (at least 56%) the activity of GST in the gills, but increased the activity of AChE in the muscle (similar to 69%) and brain (similar to 50%) after 28 d. Most importantly, after 28 d of exposure, Se exposure caused significant decrease in GSH levels in the gills (at least 35%) and in all tissues examined at the highest test concentration. In general, the results showed that Se(IV) led to faster accumulation of Se than Se(VI) in P. parva, and the resulted lipid peroxidation was closely related to the levels of antioxidants, especially GSH. Our results suggest that the ecotoxicological effects of waterborne selenite and selenate differ in this freshwater species in the field.
资助项目National Natural Science Foundation of China (NSFC)[31270549] ; National Natural Science Foundation of China (NSFC)[41807352] ; National Natural Science Foundation of China (NSFC)[41877366] ; China Agriculture Research System[CARS-46] ; Inner Mongolia Province Key Laboratory of Toxicant Monitoring and Toxicology Open Fund Project[MDK2017015] ; One-hundred Talent program of the Chinese Academy of Sciences ; China Postdoctoral Science Foundation[2018M632471]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000444571200068
出版者NATURE PUBLISHING GROUP
源URL[http://210.72.129.5/handle/321005/123139]  
专题中国科学院沈阳应用生态研究所
通讯作者Zhang, Qianru
作者单位1.Chinese Acad Sci, Inst Appl Ecol, Key Lab Pollut Ecol & Environm Engn, Shenyang 110016, Peoples R China
2.Shenyang Inst Engn, Coll Energy & Power, Key Lab Clean Combust Elect Generat & Heat Supply, Shenyang 110136, Liaoning, Peoples R China
3.Zhejiang Univ, Dept Environm Sci, Hangzhou 310058, Zhejiang, Peoples R China
4.South China Normal Univ, Environm Res Inst, MOE Key Lab Theoret Chem Environm, Guangzhou 510006, Guangdong, Peoples R China
5.Chinese Acad Sci, Inst Appl Ecol, Shenyang 110016, Liaoning, Peoples R China
6.Guangxi Acad Fishery Sci, Nanning 530021, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Shanshan,Zeng, Xiangfeng,Chen, Hongxing,et al. The differences in bioaccumulation and effects between Se(IV) and Se(VI) in the topmouth gudgeon Pseudorasbora parva[J]. SCIENTIFIC REPORTS,2018,8:12.
APA Ma, Shanshan.,Zeng, Xiangfeng.,Chen, Hongxing.,Geng, Shicong.,Yan, Liang.,...&Zhang, Qianru.(2018).The differences in bioaccumulation and effects between Se(IV) and Se(VI) in the topmouth gudgeon Pseudorasbora parva.SCIENTIFIC REPORTS,8,12.
MLA Ma, Shanshan,et al."The differences in bioaccumulation and effects between Se(IV) and Se(VI) in the topmouth gudgeon Pseudorasbora parva".SCIENTIFIC REPORTS 8(2018):12.

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来源：沈阳应用生态研究所

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