The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InRp5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study
文献类型：期刊论文
| 作者 | Dong, Yuling1,2; Sun, Hao1; Yang, Weichao1; Ma, Shuang1,2; Du, Beibei1,2; Xu, Hui1 |
| 刊名 | NUTRIENTS
 |
| 出版日期 | 2019-03-15 |
| 卷号 | 11期号:3页码:14 |
| 关键词 | inulin Drosophila melanogaster lifespan insulin insulin-like growth factor (IGF)-like signalling (IIS) pathway gut microbiota |
| ISSN号 | 2072-6643 |
| DOI | 10.3390/nu11030636 |
| 英文摘要 | Inulin is considered an efficient prebiotic and is beneficial for metabolic diseases via promoting intestinal probiotic enrichment and the metabolites of short-chain fatty acids (SCFAs). However, the effect of inulin on patients with InR deficiencies has seldom been reported. In this study, the lifespan, related gene expression, and gut microbiota of InRp5545/TM3 (insulin receptor mutant) Drosophila melanogaster under inulin treatment were investigated. The results showed that the lifespan was extended in only males and not in females. Furthermore, distinctly different patterns of gene expression were found between males and females, especially in the insulin/insulin-like growth factor (IGF)-like signalling (IIS) and target of rapamycin (TOR) pathways. Additionally, as a link between inulin and lifespan responses, the gut microbiota was distinctly separated by gender in both the standard diet group and the inulin treatment group, and the relationship between lifespan and the gut microbiota community was stronger in male flies than in females. This study provides preliminary evidence for the gender-dependent lifespan responses to inulin in insulin signalling-deficient Drosophila. However, controls such as wild-type and TM3 flies, and more InR mutant strains with different genetic backgrounds need to be further investigated to elucidate the mechanisms underlying the phenomenon. |
| 资助项目 | Joint RD projects[2019210101000356] |
| WOS研究方向 | Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:000464372300002 |
| 出版者 | MDPI |
| 源URL | [http://210.72.129.5/handle/321005/124013]  |
| 专题 | 中国科学院沈阳应用生态研究所 |
| 通讯作者 | Xu, Hui |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Pollut Ecol & Environm Engn, Inst Appl Ecol, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Yuling,Sun, Hao,Yang, Weichao,et al. The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InRp5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study[J]. NUTRIENTS,2019,11(3):14. |
| APA | Dong, Yuling,Sun, Hao,Yang, Weichao,Ma, Shuang,Du, Beibei,&Xu, Hui.(2019).The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InRp5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study.NUTRIENTS,11(3),14. |
| MLA | Dong, Yuling,et al."The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InRp5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study".NUTRIENTS 11.3(2019):14. |
入库方式： OAI收割
来源：沈阳应用生态研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。