Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice
文献类型：期刊论文
| 作者 | Chi, TY; Wang, LH; Qu, C; Yang, BZ; Ji, XF; Wang, Y; Okuyama, T; Yoshihito, O; Zou, LB; Zou, LB, Shenyang Pharmaceut Univ, Dept Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China |
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 11期号:12页码:1019-1027 |
| 关键词 | Xanthoceraside a Beta(25-35) Alzheimer's Disease Learning And Memory |
| ISSN号 | 1028-6020 |
| 英文摘要 | This study examined the effects of xanthoceraside (1) on learning and memory impairment induced in mice by intracerebroventricular injection of aggregated peptide beta-amyloid 25-35 (A beta(25-35)). Learning and memory functions in mice were examined using step-through, Y-maze and water maze tests. Administration of 1 reduced the number of errors and prolonged latency in the step-through test in mice impaired by A beta(25-35). Likewise, latency to find the terminal platform was decreased and the number of right reflects was increased in the water maze test, and the percentage of alternation behaviors in the Y-maze test was increased. Biochemical studies showed that decreased activities of superoxide dismutase, glutathione peroxidase, and acetylcholinesterase, and increased content of malondialdehyde in mice impaired by A beta(25-35) were significantly ameliorated by administration of 1. The present results suggest that 1 may provide a potential treatment strategy for Alzheimer's disease. |
| 学科主题 | Plant Sciences ; Applied ; Medicinal ; Chemistry ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000273725900006 |
| 资助机构 | Educational Department of Liaoning Province [20060880]; Shenyang Science and Technology Commission [1071060-9-00] |
| 公开日期 | 2011-09-23 |
| 源URL | [http://210.72.129.5/handle/321005/53951]  |
| 专题 | 沈阳应用生态研究所_沈阳应用生态研究所 |
| 通讯作者 | Zou, LB, Shenyang Pharmaceut Univ, Dept Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chi, TY,Wang, LH,Qu, C,et al. Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(12):1019-1027. |
| APA | Chi, TY.,Wang, LH.,Qu, C.,Yang, BZ.,Ji, XF.,...&Zou, LB, Shenyang Pharmaceut Univ, Dept Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China.(2009).Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,11(12),1019-1027. |
| MLA | Chi, TY,et al."Protective effects of xanthoceraside on learning and memory impairment induced by A beta(25-35) in mice".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 11.12(2009):1019-1027. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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