Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions
文献类型：期刊论文
| 作者 | Zhang, JH, Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, POB 17,103 Wenhua Rd, Shenyang, Liaoning Prov, Peoples R China; Zhu, J; Wang, J; Su, ZC; Li, Q; Cheng, MS; Zhang, JH |
| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 31期号:9页码:1120-1128 |
| 关键词 | Selex Ssdna Aptamers Homology Modeling Autodock |
| ISSN号 | 0253-6269 |
| 英文摘要 | Twelve ssDNA aptamers specific for a novel recombinant anti-neuroexcitation peptide (ANEPIII) were identified using the SELEX method from a 79-nucleotide ssDNA pool to purify ANEPIII in a more efficient way. To further understand the binding modes between ssDNA and ANEPIII, fully flexible dinucleotides were docked onto the homology-modeled ANEPIII structure. AutoDocking identified favorable binding sites on ANEPIII for nucleotides, which was valuable for designing more potent ligands. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000259364900007 |
| 公开日期 | 2011-09-23 |
| 源URL | [http://210.72.129.5/handle/321005/54379]  |
| 专题 | 沈阳应用生态研究所_沈阳应用生态研究所 |
| 通讯作者 | Zhang, JH, Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, POB 17,103 Wenhua Rd, Shenyang, Liaoning Prov, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, JH, Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, POB 17,103 Wenhua Rd, Shenyang, Liaoning Prov, Peoples R China,Zhu, J,Wang, J,et al. Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions[J]. ARCHIVES OF PHARMACAL RESEARCH,2008,31(9):1120-1128. |
| APA | Zhang, JH, Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, POB 17,103 Wenhua Rd, Shenyang, Liaoning Prov, Peoples R China.,Zhu, J.,Wang, J.,Su, ZC.,Li, Q.,...&Zhang, JH.(2008).Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions.ARCHIVES OF PHARMACAL RESEARCH,31(9),1120-1128. |
| MLA | Zhang, JH, Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, POB 17,103 Wenhua Rd, Shenyang, Liaoning Prov, Peoples R China,et al."Identification of ssDNA aptamers specific for anti-neuroexcitation peptide III and molecular modeling studies: Insights into structural interactions".ARCHIVES OF PHARMACAL RESEARCH 31.9(2008):1120-1128. |
入库方式： OAI收割
来源：沈阳应用生态研究所
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