Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy
文献类型：期刊论文
| 作者 | Chen, Li2; Ma, Weiqian2; He, Liang1; Hu, Yanfang2 |
| 刊名 | POLYMER INTERNATIONAL
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 67期号:12页码:1648-1654 |
| 关键词 | reduced graphene oxide (rGO) non-covalent methods bortezomib (BTZ) delivery photothermal chemotherapy |
| ISSN号 | 0959-8103 |
| DOI | 10.1002/pi.5689 |
| 通讯作者 | Chen, Li(chenl686@nenu.edu.cn) |
| 英文摘要 | In cancer treatment, it still is a curial challenge to enhance therapeutic efficacy and reduce side effects. A novel reduced graphene oxide-based nanoplatform (rGO/PDex) has been constructed to deliver an anticancer drug, bortezomib (BTZ), for photo-chemotherapy. The structure and properties of the nanoplatform were characterized. The obtained data strongly indicated that rGO/PDex had enhanced stability. Further, folic acid was introduced and the resulting rGO/PDexF nanoplatform exhibited improved cellular uptake due to the active targeting effect. The anticancer drug BTZ could be effectively encapsulated into the rGO-based nanoplatform and be released in a controlled manner. In vitro experiments demonstrated that BTZ-loaded rGO-based nanoparticles displayed enhanced therapeutic efficacy compared with the single chemotherapy, indicating the great potential of rGO-based nanoparticles for cancer treatments. (c) 2018 Society of Chemical Industry |
| WOS关键词 | PROTEASOME INHIBITORS ; DRUG-DELIVERY ; PHOTO-CHEMOTHERAPY ; MULTIPLE-MYELOMA ; CANCER-CELLS ; MICELLES ; NANOPARTICLES ; NANOSHEETS ; UBIQUITIN ; GRAPHITE |
| 资助项目 | National Natural Science Foundation of China[21474012] ; National Natural Science Foundation of China[51273037] ; Jilin Science and Technology Bureau[20130206074GX] ; Jilin Science and Technology Bureau[20120729] ; New Century Excellent Talents in University of Jilin Province[2013-6] |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000449675300007 |
| 出版者 | WILEY |
| 资助机构 | National Natural Science Foundation of China ; Jilin Science and Technology Bureau ; New Century Excellent Talents in University of Jilin Province |
| 源URL | [http://ir.ciomp.ac.cn/handle/181722/60324]  |
| 专题 | 中国科学院长春光学精密机械与物理研究所 |
| 通讯作者 | Chen, Li |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun, Jilin, Peoples R China 2.Northeast Normal Univ, Dept Chem, 5268 Renmin St, Changchun, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Li,Ma, Weiqian,He, Liang,et al. Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy[J]. POLYMER INTERNATIONAL,2018,67(12):1648-1654. |
| APA | Chen, Li,Ma, Weiqian,He, Liang,&Hu, Yanfang.(2018).Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy.POLYMER INTERNATIONAL,67(12),1648-1654. |
| MLA | Chen, Li,et al."Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy".POLYMER INTERNATIONAL 67.12(2018):1648-1654. |
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