Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy
文献类型：期刊论文
| 作者 | Zhao, Jie1; Wang, Anhe2; Si, Tieyan3; Hong, Jong-Dal4; Li, Junbai1,5 |
| 刊名 | JOURNAL OF COLLOID AND INTERFACE SCIENCE
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 549页码:9-15 |
| 关键词 | Gold nanorods Multicompartment mesoporous silica nanoparticles Ultra-stable Photostability Photothermal therapy |
| ISSN号 | 0021-9797 |
| DOI | 10.1016/j.jcis.2019.04.051 |
| 英文摘要 | Photothermal therapy (PTT) based on photothermal effect of the gold nanostructures, has been widely applied as a noninvasive therapy approach in cancer treatment. However, bare Au nanoparticles are not stable enough during the irradiation process, and cannot harvest sufficient energy to kill tumor cells. To improve this, we have fabricated a stable bioagent by loading gold nanorods (AuNRs) into multicompartment mesoporous silica nanoparticles (MMSNs) for the photothermal therapy. The procedure is that when AuNRs entrapped in MMSNs are irradiated by a laser in the near-infrared region of 808 nm, the hyperthermia produced by the assembled composites is strong enough to damage tumor tissues directly. Both experiments in vitro and in vivo demonstrate that the nanocomposites are perfect candidates as PTT agents for the cancer treatment with a high efficiency. Furthermore, it is found that the nanocomposites have good photostability and consistent temperature fluctuation over 11 on/off cycles with irradiation which the pure AuNRs will not have. (C) 2019 Elsevier Inc. All rights reserved. |
| WOS关键词 | POLYMER NANOPARTICLES ; DRUG-DELIVERY ; NANOCAGES ; GRAPHENE ; ABLATION ; CARRIER ; SHAPE |
| 资助项目 | Research Grant of Incheon National University in 2018 ; National Nature Science Foundation of China[21433010] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000469902100002 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | Research Grant of Incheon National University in 2018 ; National Nature Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/29826]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Hong, Jong-Dal; Li, Junbai |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, BNLMS, Bei Yi Jie 2, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Harbin Inst Technol, Micro Nanotechnol Res Ctr, Key Lab Microsyst & Microstruct Mfg, Harbin, Heilongjiang, Peoples R China 4.Incheon Natl Univ, Dept Chem, 119 Acad Ro, Incheon 21022, South Korea 5.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Jie,Wang, Anhe,Si, Tieyan,et al. Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,549:9-15. |
| APA | Zhao, Jie,Wang, Anhe,Si, Tieyan,Hong, Jong-Dal,&Li, Junbai.(2019).Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy.JOURNAL OF COLLOID AND INTERFACE SCIENCE,549,9-15. |
| MLA | Zhao, Jie,et al."Gold nanorods based multicompartment mesoporous silica composites as bioagents for highly efficient photothermal therapy".JOURNAL OF COLLOID AND INTERFACE SCIENCE 549(2019):9-15. |
入库方式： OAI收割
来源：过程工程研究所
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