CO-Releasing Materials: An Emphasis on Therapeutic Implications, as Release and Subsequent Cytotoxicity Are the Part of Therapy
文献类型：期刊论文
| 作者 | Faizan, Muhammad1; Muhammad, Niaz2; Niazi, Kifayat Ullah Khan3; Hu, Yongxia1; Wang, Yanyan1; Wu, Ya1; Sun, Huaming1; Liu, Ruixia4; Dong, Wensheng1; Zhang, Weiqiang1 |
| 刊名 | MATERIALS
 |
| 出版日期 | 2019-05-02 |
| 卷号 | 12期号:10页码:41 |
| 关键词 | CO administration therapeutic agent pharmaceutical drugs heme oxygenase CO-releasing materials CO-releasing molecules organometallic complexes pharmacokinetic functions pathological role CO kinetic profile cellular targets |
| ISSN号 | 1996-1944 |
| DOI | 10.3390/ma12101643 |
| 英文摘要 | The CO-releasing materials (CORMats) are used as substances for producing CO molecules for therapeutic purposes. Carbon monoxide (CO) imparts toxic effects to biological organisms at higher concentration. If this characteristic is utilized in a controlled manner, it can act as a cell-signaling agent for important pathological and pharmacokinetic functions; hence offering many new applications and treatments. Recently, research on therapeutic applications using the CO treatment has gained much attention due to its nontoxic nature, and its injection into the human body using several conjugate systems. Mainly, there are two types of CO insertion techniques into the human body, i.e., direct and indirect CO insertion. Indirect CO insertion offers an advantage of avoiding toxicity as compared to direct CO insertion. For the indirect CO inhalation method, developers are facing certain problems, such as its inability to achieve the specific cellular targets and how to control the dosage of CO. To address these issues, researchers have adopted alternative strategies regarded as CO-releasing molecules (CORMs). CO is covalently attached with metal carbonyl complexes (MCCs), which generate various CORMs such as CORM-1, CORM-2, CORM-3, ALF492, CORM-A1 and ALF186. When these molecules are inserted into the human body, CO is released from these compounds at a controlled rate under certain conditions or/and triggers. Such reactions are helpful in achieving cellular level targets with a controlled release of the CO amount. However on the other hand, CORMs also produce a metal residue (termed as i-CORMs) upon degradation that can initiate harmful toxic activity inside the body. To improve the performance of the CO precursor with the restricted development of i-CORMs, several new CORMats have been developed such as micellization, peptide, vitamins, MOFs, polymerization, nanoparticles, protein, metallodendrimer, nanosheet and nanodiamond, etc. In this review article, we shall describe modern ways of CO administration; focusing primarily on exclusive features of CORM's tissue accumulations and their toxicities. This report also elaborates on the kinetic profile of the CO gas. The comprehension of developmental phases of CORMats shall be useful for exploring the ideal CO therapeutic drugs in the future of medical sciences. |
| WOS关键词 | CARBON-MONOXIDE RELEASE ; ISCHEMIA-REPERFUSION INJURY ; EX-VIVO APPLICATION ; ON-DEMAND RELEASE ; HEME OXYGENASE-1 ; ISCHEMIA/REPERFUSION INJURY ; MOLECULE CORM-3 ; NITRIC-OXIDE ; HYBRID MATERIALS ; AQUEOUS-SOLUTION |
| 资助项目 | National Natural Science Foundation of China[21771122] ; National Natural Science Foundation of China[21571121] ; 111 Project[B14041] ; Program for Chang Jiang Scholars and Innovative Research Team in University[IRT_14R33] ; Key Research and Development Project of Shaanxi Science and Technology Department[2017SF-064] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000471012500072 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China ; 111 Project ; Program for Chang Jiang Scholars and Innovative Research Team in University ; Key Research and Development Project of Shaanxi Science and Technology Department |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/30121]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Weiqiang; Gao, Ziwei |
| 作者单位 | 1.Shaanxi Normal Univ, Sch Chem & Chem Engn, Key Lab Appl Surface & Colloid Chem MOE, Xian 710062, Shaanxi, Peoples R China 2.Shaanxi Normal Univ, Coll Life Sci, Dept Biochem, Xian 710062, Shaanxi, Peoples R China 3.Xi An Jiao Tong Univ, Sch Mat Sci & Engn, Xian 710049, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Faizan, Muhammad,Muhammad, Niaz,Niazi, Kifayat Ullah Khan,et al. CO-Releasing Materials: An Emphasis on Therapeutic Implications, as Release and Subsequent Cytotoxicity Are the Part of Therapy[J]. MATERIALS,2019,12(10):41. |
| APA | Faizan, Muhammad.,Muhammad, Niaz.,Niazi, Kifayat Ullah Khan.,Hu, Yongxia.,Wang, Yanyan.,...&Gao, Ziwei.(2019).CO-Releasing Materials: An Emphasis on Therapeutic Implications, as Release and Subsequent Cytotoxicity Are the Part of Therapy.MATERIALS,12(10),41. |
| MLA | Faizan, Muhammad,et al."CO-Releasing Materials: An Emphasis on Therapeutic Implications, as Release and Subsequent Cytotoxicity Are the Part of Therapy".MATERIALS 12.10(2019):41. |
入库方式： OAI收割
来源：过程工程研究所
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