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Transport of a graphene nanosheet sandwiched inside cell membranes

文献类型：期刊论文

作者Chen, Pengyu1; Yue, Hua2; Zhai, Xiaobo3; Huang, Zihan1; Ma, Guang-Hui2,4; Wei, Wei2,4; Yan, Li-Tang1
刊名SCIENCE ADVANCES
出版日期2019-06-01
卷号5期号:6页码:13
ISSN号2375-2548
DOI10.1126/sciadv.aaw3192
英文摘要The transport of nanoparticles at bio-nano interfaces is essential for many cellular responses and biomedical applications. How two-dimensional nanomaterials, such as graphene and transition-metal dichalcogenides, diffuse along the cell membrane is, however, unknown, posing an urgent and important issue to promote their applications in the biomedical area. Here, we show that the transport of graphene oxides (GOs) sandwiched inside cell membranes varies from Brownian to Levy and even directional dynamics. Specifically, experiments evidence sandwiched graphene-cell membrane superstructures in different cells. Combined simulations and analysis identify a sandwiched GO-induced pore in cellmembrane leaflets, spanning unstable, metastable, and stable states. An analyticalmodel that rationalizes the regimes of thesemembrane-pore states fits simulations quantitatively, resulting in amechanistic interpretation of the emergence of Levy and directional dynamics. We finally demonstrate the applicability of sandwiched GOs in enhanced efficiency of membrane-specific drug delivery. Our findings inform approaches to programming intramembrane transport of two-dimensional nanomaterials toward advantageous biomedical applications.
WOS关键词DISSIPATIVE PARTICLE DYNAMICS ; COMPUTER-SIMULATION ; DRUG-DELIVERY ; NANOPARTICLES ; NANOMATERIALS ; DIRECTIONALITY ; VESICULATION ; ENDOCYTOSIS ; CURVATURE ; DIFFUSION
资助项目National Natural Science Foundation of China[21873053] ; National Natural Science Foundation of China[51633003] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[11504290] ; National Key R&D Program of China[2016YFA0202500] ; National Key R&D Program of China[2017YFA0207900]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000473798500072
出版者AMER ASSOC ADVANCEMENT SCIENCE
资助机构National Natural Science Foundation of China ; National Key R&D Program of China
源URL[http://ir.ipe.ac.cn/handle/122111/30132]  
专题中国科学院过程工程研究所
通讯作者Wei, Wei; Yan, Li-Tang
作者单位1.Tsinghua Univ, Dept Chem Engn, State Key Lab Chem Engn, Beijing 100084, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Xian Univ Sci & Technol, Coll Sci, Xian 710054, Shaanxi, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Pengyu,Yue, Hua,Zhai, Xiaobo,et al. Transport of a graphene nanosheet sandwiched inside cell membranes[J]. SCIENCE ADVANCES,2019,5(6):13.
APA Chen, Pengyu.,Yue, Hua.,Zhai, Xiaobo.,Huang, Zihan.,Ma, Guang-Hui.,...&Yan, Li-Tang.(2019).Transport of a graphene nanosheet sandwiched inside cell membranes.SCIENCE ADVANCES,5(6),13.
MLA Chen, Pengyu,et al."Transport of a graphene nanosheet sandwiched inside cell membranes".SCIENCE ADVANCES 5.6(2019):13.

入库方式： OAI收割

来源：过程工程研究所

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