Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly
文献类型：期刊论文
| 作者 | Ji, Wei1; Yuan, Chengqian2; Zilberzwige-Tal, Shai1; Xin, Ruirui2; Chakraborty, Priyadarshi1; Tao, Kai1; Gilead, Sharon1; Yan, Xuehai2; Gazit, Ehud1,3 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2019-06-01 |
| 卷号 | 13期号:6页码:7300-7309 |
| 关键词 | hydrogels self-assembly nanostructures dipeptide supramolecular chemistry |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.9b03444 |
| 英文摘要 | The misfolding of proteins and peptides potentially leads to a conformation transition from an alpha-helix or random coil to beta-sheet-rich fibril structures, which are associated with various amyloid degenerative disorders. Inhibition of the beta-sheet aggregate formation and control of the structural transition could therefore attenuate the development of amyloid-associated diseases. However, the structural transitions of proteins and peptides are extraordinarily complex processes that are still not fully understood and thus challenging to manipulate. To simplify this complexity, herein, the effect of metal ions on the inhibition of amyloid-like beta-sheet dipeptide self assembly is investigated. By changing the type and ratio of the metal ion/dipeptide mixture, structural transformation is achieved from a beta-sheet to a superhelix or random coil, as confirmed by experimental results and computational studies. Furthermore, the obtained supramolecular metallogel exhibits excellent in vitro DNA binding and diffusion capability due to the positive charge of the metal/dipeptide complex. This work may facilitate the understanding of the role of metal ions in inhibiting amyloid formation and broaden the future applications of supramolecular metallogels in three-dimensional (3D) DNA biochip, cell culture, and drug delivery. |
| WOS关键词 | FIBRILS ; DIPHENYLALANINE ; TRANSITION ; HYDROGELS ; POLYMORPHISM ; ETIOLOGY ; BINDING |
| 资助项目 | European Research Council under the European Union[694426] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000473248300116 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | European Research Council under the European Union ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/30261]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yan, Xuehai; Gazit, Ehud |
| 作者单位 | 1.Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-6997801 Tel Aviv, Israel 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Tel Aviv Univ, Iby & Aladar Fleischman Fac Engn, Dept Mat Sci & Engn, IL-6997801 Tel Aviv, Israel |
| 推荐引用方式 GB/T 7714 | Ji, Wei,Yuan, Chengqian,Zilberzwige-Tal, Shai,et al. Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly[J]. ACS NANO,2019,13(6):7300-7309. |
| APA | Ji, Wei.,Yuan, Chengqian.,Zilberzwige-Tal, Shai.,Xin, Ruirui.,Chakraborty, Priyadarshi.,...&Gazit, Ehud.(2019).Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly.ACS NANO,13(6),7300-7309. |
| MLA | Ji, Wei,et al."Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly".ACS NANO 13.6(2019):7300-7309. |
入库方式： OAI收割
来源：过程工程研究所
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