Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr
文献类型：期刊论文
| 作者 | Wei, Fenfen1; He, Qinghua1; Wang, Wenjuan1; Pei, Dong2; Zhang, Bo1 |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2019 |
| 页码 | 10 |
| ISSN号 | 1741-427X |
| DOI | 10.1155/2019/9819643 |
| 通讯作者 | Zhang, Bo(zhangbo_wl@buu.edu.cn) |
| 英文摘要 | Cynomorium songaricum Rupr, known as Suo Yang, is most commonly used to treat fatigue, protect the liver, and invigorate kidneys in Northwest China. Given the wide medicinal utilisation and lack of safety evaluation, this work evaluated the acute toxicity, genetic toxicity, and 90-day repeated oral toxicity of Suo Yang. Twenty Kunming mice were orally given Suo Yang once and observed for 14 days in the acute toxicity test. The genetic toxicity of Suo Yang was tested using in vivo and vitro assays (bacterial reverse mutation test, mouse bone marrow micronucleus assay, and spermatocyte chromosomal aberration assay). In the 90-day repeated oral toxicity study, 80 SD rats were randomly divided into 4 groups and then orally given Suo Yang at different concentrations (1.04, 2.08 or 4.16g/kg), while the control group was given sterile water. In the acute toxicity test, no abnormal behaviour or mortality was found in mice. The results suggest that the maximum tolerable dose of Suo Yang is greater than 15g/kg. In the genotoxicity studies, no revertant colonies were produced in vitro. In the in vivo assays, no increased frequencies of micronuclei or structural abnormalities of spermatocyte chromosomes were found. In the 90-day repeated oral toxicity study, no significant toxicological manifestations were observed in haematological parameters or clinical and pathological examinations. In summary, these results suggest that Suo Yang at the given doses does not cause adverse effects in animals. Thus, Suo Yang can reasonably be considered a safe herbal medicine. |
| 收录类别 | SCI |
| WOS关键词 | SAFETY PHARMACOLOGY ; SUBCHRONIC TOXICITY ; ENHANCEMENT ; PROTECTION ; ACID |
| WOS研究方向 | Integrative & Complementary Medicine |
| WOS类目 | Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000461640900001 |
| 出版者 | HINDAWI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2555556 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Zhang, Bo |
| 作者单位 | 1.Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, Beijing, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Fenfen,He, Qinghua,Wang, Wenjuan,et al. Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2019:10. |
| APA | Wei, Fenfen,He, Qinghua,Wang, Wenjuan,Pei, Dong,&Zhang, Bo.(2019).Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,10. |
| MLA | Wei, Fenfen,et al."Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019):10. |
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来源：寒区旱区环境与工程研究所
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