Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties
文献类型：期刊论文
| 作者 | Sun, Ya-Xuan2,3; Tang, Yue4,5; Wu, Ai-Li4,5; Liu, Ting6; Dai, Xue-Ling2; Zheng, Qiu-Sheng6; Wang, Zhi-Bin1 |
| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 12期号:12页码:1051-1060 |
| 关键词 | liquiritin mice focal cerebral ischemia reperfusion antioxidant anti-apoptosis |
| ISSN号 | 1028-6020 |
| DOI | 10.1080/10286020.2010.535520 |
| 通讯作者 | Wang, Zhi-Bin(wangzhibin4804@sina.com) |
| 英文摘要 | Our present study was conducted to investigate whether liquiritin (7-hydroxy-2-[4-[3,4,5-trihydroxy-6-(hydroxymethyl) oxan-2-yl] oxyphenyl]-chroman-4-one, 1), an active component of Glycyrrhiza uralensis Fisch., exerts a neuroprotective effect against focal cerebral ischemia/reperfusion (I/R) in male Institute of Cancer Research (ICR) mice. On the establishment of mice with middle cerebral artery occlusion (MCAO) for 2h and reperfusion for 22h, liquiritin at the doses of 40, 20, and 10mg/kg was administered before MCAO once a day intragastrically for a subsequent 3 days. Neurological deficits and infarct volume were measured, respectively. The levels of malondialdehyde (MDA) and carbonyl, activities of superoxide anion (SOD), catalase (CAT) and glutathion peroxidase (GSH-Px) and reduced glutathione/oxidized disulfide (GSH/GSSG) ratio in brain were estimated spectrophotometrically. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and terminal deoxynucleotidyl transferase-mediated DuTP-biotin nick end labeling (TUNEL)-positive cells were detected by immunohistochemical analysis. Our results showed that the neurological deficits, infarct volume, and the levels of MDA and carbonyl decreased, the ratio of GSH/GSSG and the activities of SOD, CAT, and GSH-Px were compensatorily up-regulated, and 8-OHdG and TUNEL-positive cells decreased after 22h of reperfusion in liquiritin-treated groups. These findings suggest that liquiritin might be a potential agent against cerebral I/R injury in mice by its antioxidant and antiapoptosis properties. |
| 收录类别 | SCI |
| WOS关键词 | ARTERY OCCLUSION ; ISCHEMIC-STROKE ; RATS ; GERBILS ; INJURY ; DAMAGE ; MECHANISMS ; LICORICE ; DEATH ; ACID |
| WOS研究方向 | Plant Sciences ; Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000284891600007 |
| 出版者 | TAYLOR & FRANCIS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2556408 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Wang, Zhi-Bin |
| 作者单位 | 1.Beijing Inst Drug Control, Beijing 100035, Peoples R China 2.Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Cold & Arid Reg Environm & Engn Res Inst, Lanzhou 730000, Peoples R China 4.Chinese Acad Med Sci, Peking Union Med Coll, Fuwai Hosp, Beijing 100037, Peoples R China 5.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China 6.Shihezi Univ, Minist Educ, Sch Pharm, Key Lab Xinjiang Endem Phytomed Resources, Shihezi 832002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Ya-Xuan,Tang, Yue,Wu, Ai-Li,et al. Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2010,12(12):1051-1060. |
| APA | Sun, Ya-Xuan.,Tang, Yue.,Wu, Ai-Li.,Liu, Ting.,Dai, Xue-Ling.,...&Wang, Zhi-Bin.(2010).Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,12(12),1051-1060. |
| MLA | Sun, Ya-Xuan,et al."Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 12.12(2010):1051-1060. |
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来源：寒区旱区环境与工程研究所
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