Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.)
文献类型：期刊论文
| 作者 | Wei, Jianteng1,2,3,4; Wang, Shuxian5; Pei, Dong2,3,4; Qu, Liangjing5; Li, Ya1; Chen, Jianjun1; Di, Duolong2,3,4; Gao, Kun1 |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2018 |
| 卷号 | 32期号:16页码:1967-1970 |
| 关键词 | Hydroxytyrosol acetate olive leaves antibacterial activity DNA interaction |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2017.1356830 |
| 通讯作者 | Di, Duolong(didl@licp.cas.cn) ; Gao, Kun(npchem@lzu.edu.cn) |
| 英文摘要 | Vibrio spp. are pathogens of many bacterial diseases which have caused great economic losses in marine aquaculture. The strategy of alternative medical treatment that is utilised by herbalists has expanded in the past decade. The aim of our study is to discover the antibacterial molecules against Vibrio spp. Bacterial growth inhibition, membrane permeabilisation assessmentand DNA interaction assays, as well as agarose gel electrophoresis, were employed to elucidate the antibacterial activity of hydroxytyrosol acetate. Results showed that hydroxytyrosol acetate had antibacterial activity against Vibrio spp. and it played the role via increasing bacterial membrane permeabilisation. The DNA interaction assay and agarose gel electrophoresis revealed that hydroxytyrosol acetate interacted with DNA. Hydroxytyrosol acetate enhanced the fluorescent intensity of DNA binding molecules and mediated supercoiled DNA relaxation. The present study provides more evidence that hydroxytyrosol acetate is a novel antibacterial candidate against Vibrio spp. [GRAPHICS] . |
| 收录类别 | SCI |
| WOS关键词 | VIBRIO-ALGINOLYTICUS ; IN-VITRO ; DNA ; MECHANISM ; BINDING ; ANTIMICROBIALS ; INFECTION ; TARGET ; IMMUNE ; PLANTS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Applied ; Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000440365200013 |
| 出版者 | TAYLOR & FRANCIS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2557781 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Di, Duolong; Gao, Kun |
| 作者单位 | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou, Gansu, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou, Gansu, Peoples R China 4.Ctr Resource Chem & New Mat, Qingdao, Peoples R China 5.Marine Biol Inst Shandong Prov, Ctr Fishery Dis & Drug, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Jianteng,Wang, Shuxian,Pei, Dong,et al. Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.)[J]. NATURAL PRODUCT RESEARCH,2018,32(16):1967-1970. |
| APA | Wei, Jianteng.,Wang, Shuxian.,Pei, Dong.,Qu, Liangjing.,Li, Ya.,...&Gao, Kun.(2018).Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.).NATURAL PRODUCT RESEARCH,32(16),1967-1970. |
| MLA | Wei, Jianteng,et al."Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.)".NATURAL PRODUCT RESEARCH 32.16(2018):1967-1970. |
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来源：寒区旱区环境与工程研究所
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