Caspase-9: structure, mechanisms and clinical application
文献类型：期刊论文
| 作者 | Li, Ping1,2,3; Zhou, Libin1; Zhao, Ting1,2,3; Liu, Xiongxiong1,2,3; Zhang, Pengcheng1,2,3,4; Liu, Yan1,2,3,4; Zheng, Xiaogang1,2,3,4; Li, Qiang1,2,3 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017 |
| 卷号 | 8期号:14页码:23996-24008 |
| 关键词 | caspase-9 apoptosis phosphorylation alternative splicing iCasp9 |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.15098 |
| 通讯作者 | Li, Qiang(liqiang@impcas.ac.cn) |
| 英文摘要 | As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thought of involving homo-dimerization monomeric zymogens. Failing to activate caspase-9 has profound physiological and pathophysiological outcomes, leading to degenerative and developmental disorders even cancer. To govern the apoptotic commitment process appropriately, plenty of proteins and small molecules involved in regulating caspase-9. Therefore, this review is to summarize recent pertinent literature on the comprehensive description of the molecular events implicated in caspase-9 activation and inhibition, as well as the clinical trials in progress to give deep insight into caspase-9 for suppressing cancer. We hope that our concerns will be helpful for further clinical studies addressing the roles of caspase-9 and its regulators demanded to identify more effective solutions to overcome intrinsic apoptosis-related diseases especially cancer. |
| 收录类别 | SCI |
| WOS关键词 | DEATH PROTEASE CASPASE-9 ; INDUCED PROXIMITY MODEL ; PRE-MESSENGER-RNA ; CYTOCHROME-C ; CELL-DEATH ; T-CELLS ; SUICIDE-GENE ; PROSTATE-CANCER ; SAFETY SWITCH ; NITRIC-OXIDE |
| WOS研究方向 | Oncology ; Cell Biology |
| WOS类目 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000398211100139 |
| 出版者 | IMPACT JOURNALS LLC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2558006 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Li, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ping,Zhou, Libin,Zhao, Ting,et al. Caspase-9: structure, mechanisms and clinical application[J]. ONCOTARGET,2017,8(14):23996-24008. |
| APA | Li, Ping.,Zhou, Libin.,Zhao, Ting.,Liu, Xiongxiong.,Zhang, Pengcheng.,...&Li, Qiang.(2017).Caspase-9: structure, mechanisms and clinical application.ONCOTARGET,8(14),23996-24008. |
| MLA | Li, Ping,et al."Caspase-9: structure, mechanisms and clinical application".ONCOTARGET 8.14(2017):23996-24008. |
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来源：寒区旱区环境与工程研究所
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