Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells
文献类型：期刊论文
| 作者 | Liu, Yan1,2,3,4; Zhang, Pengcheng1,2,3,4; Li, Feifei1,2,3,4; Jin, Xiaodong1,2,3; Li, Jin5; Chen, Weiqiang1,2,3; Li, Qiang1,2,3 |
| 刊名 | THERANOSTICS
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:7页码:1824-1849 |
| ISSN号 | 1838-7640 |
| 关键词 | tumor radiation therapy metal-based nanoparticles NanoEnhancers radiosensitization synergistic chemo-radiotherapy |
| DOI | 10.7150/thno.22172 |
| 通讯作者 | Chen, Weiqiang(chenwq7315@impcas.ac.cn) ; Li, Qiang(liqiang@impcas.ac.cn) |
| 英文摘要 | Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed. |
| 收录类别 | SCI |
| WOS关键词 | GADOLINIUM-BASED NANOPARTICLES ; CERIUM OXIDE NANOPARTICLES ; ENDOPLASMIC-RETICULUM STRESS ; NEUTRON-CAPTURE THERAPY ; X-RAY-IRRADIATION ; BREAST-CANCER CELLS ; MRI CONTRAST AGENTS ; MEGAVOLTAGE RADIATION ENERGIES ; UNFOLDED PROTEIN RESPONSE ; DRUG-DELIVERY SYSTEMS |
| WOS研究方向 | Research & Experimental Medicine |
| WOS类目 | Medicine, Research & Experimental |
| 语种 | 英语 |
| 出版者 | IVYSPRING INT PUBL |
| WOS记录号 | WOS:000425394000006 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2558110 |
| 专题 | 寒区旱区环境与工程研究所 |
| 通讯作者 | Chen, Weiqiang; Li, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, State Key Lab Grassland Agroecosyst, Lanzhou, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yan,Zhang, Pengcheng,Li, Feifei,et al. Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells[J]. THERANOSTICS,2018,8(7):1824-1849. |
| APA | Liu, Yan.,Zhang, Pengcheng.,Li, Feifei.,Jin, Xiaodong.,Li, Jin.,...&Li, Qiang.(2018).Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells.THERANOSTICS,8(7),1824-1849. |
| MLA | Liu, Yan,et al."Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells".THERANOSTICS 8.7(2018):1824-1849. |
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来源：寒区旱区环境与工程研究所
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