Tumor necrosis factor alpha attenuates glutamine-enhanced skeletal muscle protein synthesis in rats
文献类型：期刊论文
| 作者 | Zhou, Jihong; Li, Yousheng; Liu, Fangnan; Cao, Yacheng; Li, Jieshou |
| 刊名 | NUTRITION RESEARCH
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 27期号:12页码:772-777 |
| 关键词 | total parenteral nutrition glutamine TNF-alpha stable isotope fractional synthesis rate rat |
| ISSN号 | 0271-5317 |
| DOI | 10.1016/j.nutres.2007.09.010 |
| 通讯作者 | Li, Yousheng(liys@medmail.com.cn) |
| 英文摘要 | Glutamine has been widely used in critical illness, surgery, and injury. Previous studies showed that the use of glutamine in nutritional regimens for patients with sepsis was not as effective as in patients of trauma, especially in the early stage of sepsis. The objective of this study was to determine whether the regulation of glutamine on protein synthesis in skeletal muscle could be inhibited by tumor necrosis factor alpha (TNF-alpha), one of the major mediators in sepsis in a rat model, Thirty mate Sprague-Dawley rats were randomly assigned into 3 groups: total parenteral nutrition (TPN; control), Gln (treated with glutamine), and TNF-alpha (treated with glutamine and TNF-alpha). All rats received isonitrogenous and isoenergetic TPN solutions for 3 days, The control group was supplemented with TPN, the glutamine group was given glutamine-enriched TPN, and the TNF-alpha group was supplemented with glutamine-enriched TPN followed by intravenously infused TNF-alpha in the last 24 hours. In the last 30 minutes, all rats were mainlined with [L-N-15]leucine, The concentrations of TNF-alpha and glutamine in plasma and skeletal muscle were measured, and the fractional synthesis rate was assessed. The level of TNF-alpha in the TNF-alpha group was the highest among the 3 groups. The glutamine concentration was elevated more in the TNF-alpha group than in the other 2 groups (P <.05). The fractional synthesis rate increased significantly in the TNF-alpha and On groups than that in the control group, and it was the highest in the Gln group (P < .05). In conclusion, TNF-alpha could attenuate protein synthesis in the skeletal muscle stimulated by glutamine in the early stage of sepsis in rats. (c) 2007 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| WOS关键词 | CRITICALLY-ILL PATIENTS ; SUPPLEMENTED PARENTERAL-NUTRITION ; AMINO-ACIDS ; TRANSLATION INITIATION ; ENTERAL NUTRITION ; GROWTH-HORMONE ; IN-VIVO ; SEPSIS ; METABOLISM ; KINETICS |
| WOS研究方向 | Nutrition & Dietetics |
| WOS类目 | Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:000251535500006 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2558729 |
| 专题 | 南京土壤研究所 |
| 通讯作者 | Li, Yousheng |
| 作者单位 | 1.Nanjing Univ, Jinling Hosp, Dept Gen Surg, Sch Med, Nanjing 210002, Peoples R China 2.Chinese Acad Sci, Inst Soil Sci, Nanjing 210002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Jihong,Li, Yousheng,Liu, Fangnan,et al. Tumor necrosis factor alpha attenuates glutamine-enhanced skeletal muscle protein synthesis in rats[J]. NUTRITION RESEARCH,2007,27(12):772-777. |
| APA | Zhou, Jihong,Li, Yousheng,Liu, Fangnan,Cao, Yacheng,&Li, Jieshou.(2007).Tumor necrosis factor alpha attenuates glutamine-enhanced skeletal muscle protein synthesis in rats.NUTRITION RESEARCH,27(12),772-777. |
| MLA | Zhou, Jihong,et al."Tumor necrosis factor alpha attenuates glutamine-enhanced skeletal muscle protein synthesis in rats".NUTRITION RESEARCH 27.12(2007):772-777. |
入库方式： iSwitch采集
来源：南京土壤研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。