Complexation of Al(III) with reduced glutathione in acidic aqueous solutions
文献类型：期刊论文
| 作者 | Wang, Xianlong1,2; Li, Kun1; Yang, Xiao Di1,3; Wang, Ling Ling1; Shen, Ren Fang3 |
| 刊名 | JOURNAL OF INORGANIC BIOCHEMISTRY
 |
| 出版日期 | 2009-05-01 |
| 卷号 | 103期号:5页码:657-665 |
| 关键词 | Reduced glutathione Aluminum(III) Speciation |
| ISSN号 | 0162-0134 |
| DOI | 10.1016/j.jinorgbio.2008.11.007 |
| 通讯作者 | Yang, Xiao Di(yangxiaodi@njnu.edu.cn) |
| 英文摘要 | The complexation of reduced glutathione (GSH) in its free and Al(III) bound species in acidic aqueous solutions was charaterized by means of multi-analytical techniques; pH-potentiometry, multinuclear ((1)H, (13)C and (27)Al) and two-dimensional nuclear Overhauser enhancement NMR spectroscopy ((1)H, (1)H-NOESY), electrospray mass spectroscopy (ESI-MS), and ab initio electronic structure calculations. The following results were found. In the 25 degrees C 0.1 M KCl and 37 degrees C 0.15 M NaCl ionic medium systems, Al(3+) coordinates with the important biomolecule GSH through carboxylate groups to form various mononuclear 1:1 (AlHL, AlH(2)L and AlH(-1)L), 1:2 (AlL(2)) complexes, and dinuclear (Al(2)H(5)L(2)) species, where H(4)L(+) denotes totally protonated GSH. Besides the monodentate complexes through carboxylate groups, the amino groups and the peptide bond imino and carbonyl groups may also be involved in binding with Al(3+) in the bidentate and tridentate complexes. The present data reinforce that the glycine carboxylate group of GSH has a higher microscopic complex formation constant than gamma-glutamyl carboxylate. Compared with simple amino acids, the tripeptide GSH displays a greater affinity for the Al(3+) ion and thus may interfere with aluminum's biological role more significantly. (C) 2009 Elsevier Inc. All rights reserved. |
| 收录类别 | SCI |
| WOS关键词 | COMPACT EFFECTIVE POTENTIALS ; EXPONENT BASIS-SETS ; GLUTAMATE-DEHYDROGENASE ; AMINO-ACIDS ; MULTI-NMR ; AL-III ; ALUMINUM ; METABOLISM ; DISEASE ; SYSTEMS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear |
| 语种 | 英语 |
| WOS记录号 | WOS:000265758200001 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2558794 |
| 专题 | 南京土壤研究所 |
| 通讯作者 | Yang, Xiao Di |
| 作者单位 | 1.Nanjing Normal Univ, Coll Chem & Environm Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210097, Peoples R China 2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu 610054, Peoples R China 3.Chinese Acad Sci, Inst Soil Sci, State Key Lab Soil & Sustainable Agr, Nanjing 210008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xianlong,Li, Kun,Yang, Xiao Di,et al. Complexation of Al(III) with reduced glutathione in acidic aqueous solutions[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2009,103(5):657-665. |
| APA | Wang, Xianlong,Li, Kun,Yang, Xiao Di,Wang, Ling Ling,&Shen, Ren Fang.(2009).Complexation of Al(III) with reduced glutathione in acidic aqueous solutions.JOURNAL OF INORGANIC BIOCHEMISTRY,103(5),657-665. |
| MLA | Wang, Xianlong,et al."Complexation of Al(III) with reduced glutathione in acidic aqueous solutions".JOURNAL OF INORGANIC BIOCHEMISTRY 103.5(2009):657-665. |
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来源：南京土壤研究所
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