Differential enantioselectivity of quizalofop ethyl and its acidic metabolite: Direct enantiomeric separation and assessment of multiple toxicological endpoints
文献类型：期刊论文
| 作者 | Zhang, Xiaoxiang1,2; Wang, Se1; Wang, Yu1; Xia, Tingting1; Chen, Jingwen1; Cai, Xiyun1,2 |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2011-02-15 |
| 卷号 | 186期号:1页码:876-882 |
| ISSN号 | 0304-3894 |
| 关键词 | Quizalofop ethyl Algae Transformation products Chiral Toxicological effects |
| DOI | 10.1016/j.jhazmat.2010.11.081 |
| 通讯作者 | Cai, Xiyun(xiyuncai@dlut.edu.cn) |
| 英文摘要 | Transformation products usually differ in environmental and toxicological properties compared to the parent contaminants, thus causing potential and unknown environmental risks. To elucidate differential chiral recognition of the aryloxypropanoate herbicide quizalofop ethyl (QE) and its primary product (quizalofop acid, QA). their enantiomeric separation and toxicological impacts to two freshwater algae were investigated. Addition of trace water (0.02-0.08%, v/v) to the mobile phase selectively affected retention of analyte and induced simultaneous enantio-separation for the two compounds with intrinsical water-specific resolution mechanisms, although they both possessed a chiral center in the 2-position of propionates. In algal suspensions, QE was rapidly degraded to produce the acid metabolite (QA), and the product further declined, whereas a reduction of QA as starting compound did not occur. Uptake and/or transformation of QE and QA were found a lack of enantioselectivity and isomer inversion, while cellular membrane permeability, membrane potential and algal growth showed enantioselectivity to different extents. These results suggested the presence of receptor chirality that was involved in the toxicological processes but invalid for uptake and transformation. Therefore, quizalofop acid, identified as environmentally relevant contaminant associated with application of the herbicide, participated in the toxicological processes of the parent compound, and exhibited distinct toxicological and chromatographic retention properties. (C) 2010 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| WOS关键词 | CHIRAL STATIONARY-PHASE ; ACETYL-COA CARBOXYLASE ; COENZYME-A CARBOXYLASE ; TRANSFORMATION PRODUCTS ; HERBICIDE DICLOFOP ; ORGANIC POLLUTANTS ; MASS-SPECTROMETRY ; PESTICIDES ; MECHANISM ; TOXICITY |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| WOS类目 | Engineering, Environmental ; Engineering, Civil ; Environmental Sciences |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000288102400112 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2558874 |
| 专题 | 南京土壤研究所 |
| 通讯作者 | Cai, Xiyun |
| 作者单位 | 1.Dalian Univ Technol, Sch Environm Sci & Technol, Minist Educ, Key Lab Ind Ecol & Environm Engn, Dalian 116024, Liaoning Prov, Peoples R China 2.Chinese Acad Sci, Inst Soil Sci, State Key Lab Soil & Sustainable Agr, Nanjing 210008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaoxiang,Wang, Se,Wang, Yu,et al. Differential enantioselectivity of quizalofop ethyl and its acidic metabolite: Direct enantiomeric separation and assessment of multiple toxicological endpoints[J]. JOURNAL OF HAZARDOUS MATERIALS,2011,186(1):876-882. |
| APA | Zhang, Xiaoxiang,Wang, Se,Wang, Yu,Xia, Tingting,Chen, Jingwen,&Cai, Xiyun.(2011).Differential enantioselectivity of quizalofop ethyl and its acidic metabolite: Direct enantiomeric separation and assessment of multiple toxicological endpoints.JOURNAL OF HAZARDOUS MATERIALS,186(1),876-882. |
| MLA | Zhang, Xiaoxiang,et al."Differential enantioselectivity of quizalofop ethyl and its acidic metabolite: Direct enantiomeric separation and assessment of multiple toxicological endpoints".JOURNAL OF HAZARDOUS MATERIALS 186.1(2011):876-882. |
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来源：南京土壤研究所
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