Magnetically-focusing biochip structures for high-speed active biosensing with improved selectivity
文献类型:期刊论文
作者 | Yoo, Haneul1,2; Lee, Dong Jun3; Kim, Daesan3; Park, Juhun1,2; Chen, Xing1,2,4; Hong, Seunghun1,2,3 |
刊名 | NANOTECHNOLOGY |
出版日期 | 2018-06-29 |
卷号 | 29期号:26页码:11 |
ISSN号 | 0957-4484 |
关键词 | magnetic trap-and-release magnetic nanobead high speed immunoassay biosensor magnetically-focusing |
DOI | 10.1088/1361-6528/aabc4d |
英文摘要 | We report a magnetically-focusing biochip structure enabling a single layered magnetic trap-and-release cycle for biosensors with an improved detection speed and selectivity. Here, magnetic beads functionalized with specific receptor molecules were utilized to trap target molecules in a solution and transport actively to and away from the sensor surfaces to enhance the detection speed and reduce the non-specific bindings, respectively. Using our method, we demonstrated the high speed detection of IL-13 antigens with the improved detection speed by more than an order of magnitude. Furthermore, the release step in our method was found to reduce the nonspecific bindings and improve the selectivity and sensitivity of biosensors. This method is a simple but powerful strategy and should open up various applications such as ultra-fast biosensors for point-of-care services. |
WOS关键词 | LINKED-IMMUNOSORBENT-ASSAY ; ATOMIC-FORCE MICROSCOPY ; ELECTROCHEMICAL PEPTIDE ; ENZYME-IMMUNOASSAY ; OPTICAL TWEEZERS ; DNA BIOSENSORS ; NANOPARTICLES ; ANTIBODIES ; SENSORS ; MICROARRAYS |
资助项目 | National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning (MSIP) of Korea[2013M3A6B2078961] ; National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning (MSIP) of Korea[2014M3A7B4051591] ; National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning (MSIP) of Korea[2017R1A2B2006808] ; European Research Council (ERC) under the European Union's Horizon Research and Innovation Programme[682286] |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
出版者 | IOP PUBLISHING LTD |
WOS记录号 | WOS:000431353200001 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/36223] |
专题 | 合肥物质科学研究院_中科院合肥智能机械研究所 |
通讯作者 | Hong, Seunghun |
作者单位 | 1.Seoul Natl Univ, Dept Phys & Astron, Seoul 08826, South Korea 2.Seoul Natl Univ, Inst Appl Phys, Seoul 08826, South Korea 3.Seoul Natl Univ, Dept Biophys & Chem Biol, Seoul 08826, South Korea 4.Chinese Acad Sci, Res Ctr Biomimet Funct Mat & Sensing Devices, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Yoo, Haneul,Lee, Dong Jun,Kim, Daesan,et al. Magnetically-focusing biochip structures for high-speed active biosensing with improved selectivity[J]. NANOTECHNOLOGY,2018,29(26):11. |
APA | Yoo, Haneul,Lee, Dong Jun,Kim, Daesan,Park, Juhun,Chen, Xing,&Hong, Seunghun.(2018).Magnetically-focusing biochip structures for high-speed active biosensing with improved selectivity.NANOTECHNOLOGY,29(26),11. |
MLA | Yoo, Haneul,et al."Magnetically-focusing biochip structures for high-speed active biosensing with improved selectivity".NANOTECHNOLOGY 29.26(2018):11. |
入库方式: OAI收割
来源:合肥物质科学研究院
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