Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries
文献类型：期刊论文
| 作者 | Huang, Hongbo; Yang, Zhijie1; Zhang, Chunyan1; Ma, Junying; Sun, Changli; Ju, Jianhua1; Li, Qinglian; Qin, Xiangjing |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2018 |
| 卷号 | 20期号:23页码:7633 |
| ISSN号 | 1523-7060 |
| 英文摘要 | A silent dibenzoxazepinone (DBP) biosynthetic gene cluster (myc) was mutagenically activated in Streptomyces olivaceus SCSIO T05, enabling the discovery of mycemycin C (4) and three new analogues [mycemycins F-H (1-3)]. Gene disruption, complementation experiments, and enzymatic assays unveiled salicylic acid and 5-Cl-kynurenine as biosynthetic precursors and shed significant functional insights into MycO, MycB, MycR, and MycJ, enzymes responsible for fine-tuning of the DBP scaffold. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17594]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Hongbo,Yang, Zhijie,Zhang, Chunyan,et al. Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries[J]. ORGANIC LETTERS,2018,20(23):7633, 7636. |
| APA | Huang, Hongbo.,Yang, Zhijie.,Zhang, Chunyan.,Ma, Junying.,Sun, Changli.,...&Qin, Xiangjing.(2018).Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries.ORGANIC LETTERS,20(23),7633. |
| MLA | Huang, Hongbo,et al."Genome Mining for Mycemycin: Discovery and Elucidation of Related Methylation and Chlorination Biosynthetic Chemistries".ORGANIC LETTERS 20.23(2018):7633. |
入库方式： OAI收割
来源：南海海洋研究所
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