Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49
文献类型：期刊论文
| 作者 | Xu, Jinhuai2; Tian, Yongqi2; Xu, Jiangping; Liu, Yonghong1; Chen, Yaping; Chen, Ruyan2 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2018 |
| 卷号 | 23期号:11页码:2844 |
| 关键词 | sponge-derived fungus Alternaria sp SCSIOS02F49 altenusin/thiazole hybrids benzothiazole derivative |
| ISSN号 | 1420-3049 |
| 英文摘要 | Two novel altenusin-thiazole hybrids named altenusinoides A and B (1 and 2), a new benzothiazole derivative (3), and three known altenusin derivatives (4-6) have been obtained from the solid culture of the marine sponge-derived fungal strain, Alternaria sp. SCSIOS02F49. The structures of these new compounds were characterized by NMR, HRESIMS, and X-ray single crystal analysis. Compounds 1 and 2 possess an unusual altenusin-thiazole-fused skeleton core (6/6/5), and compound 3 represents the first benzothiazole derivative from fungi. Compounds 4 and 5 showed significant DPPH free-radical-scavenging activities with the prominent IC50 values of 10.7 +/- 0.09 M and 100.6 +/- 0.025 mu M, respectively. Additionally, compound 5 exhibited COX-2 inhibitory activity with an IC50 value of 9.5 +/- 0.08 mu M. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17611]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Fuzhou Univ, Coll Biol Sci & Technol, Fuzhou 350116, Fujian, Peoples R China 2.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jinhuai,Tian, Yongqi,Xu, Jiangping,et al. Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49[J]. MOLECULES,2018,23(11):2844. |
| APA | Xu, Jinhuai,Tian, Yongqi,Xu, Jiangping,Liu, Yonghong,Chen, Yaping,&Chen, Ruyan.(2018).Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49.MOLECULES,23(11),2844. |
| MLA | Xu, Jinhuai,et al."Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp SCSIOS02F49".MOLECULES 23.11(2018):2844. |
入库方式： OAI收割
来源：南海海洋研究所
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