Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis
文献类型：期刊论文
| 作者 | Ye, Fei; Guo, Yuewei; Huang, Hui1; Mao, Shuichun2; Li, Songwei2; Zhu, Zhengdan |
| 刊名 | ACTA PHARMACEUTICA SINICA B
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:6页码:944 |
| 关键词 | Soft coral Sureophyton Sarcophyton mililatensis Cembrane-type diterpenoids Modified Mosher's method ECD calculation Cytotoxieity NE-kappa B inhibitory activity |
| ISSN号 | 2211-3835 |
| 英文摘要 | Eight cembrane-type diterpenoids, namely, (+)-(6R)-6-hydroxyisosarcophytoxide (1), (+)-(6R)-6-acetoxyisosarcophytoxide (2), (+)-17-hydroxyisosarcophytoxide (3), sarcomililatins A-D (4-7), and sarcomililatol (8), were isolated from the soft coral Sarcophyton mililatensis collected from Weizhou Island, Guangxi Autonomous Region, together with 2 known related analogues, (+)-isosarco phytoxide (9) and (+)-isosarcophine (10). The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. The absolute configuration of compound 1 was established by the modified Mosher's method, while the absolute configurations of compounds 4 and 5 were assigned by electronic circular dichroism (ECD) spectroscopy and that of compound 8 was established by time-dependent density functional theory electronic circular dichroism (TD-DFT ECD) calculation. In in vitro bioassays, compound 9 displayed significant cytotoxicity against the human cancer cell lines human promyelocytic leukemia cells (HL-60) and human lung adenocarcinoma cells (A-549) with IC50 values of 0.78 +/- 0.21 and 1.26+0.80 +/- 1.26+0.80 mu mol/L, respectively. Compounds 4 and 9 also showed moderate inhibitory effects on the TNF alpha-induced Nuclear factor kappa B (NF-kappa B, a therapeutical target in cancer) activation, showing IC50 values of 35.23 +/- 12.42 and 22.52 +/- 4.44 mu mol/L, respectively. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17625]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Fei,Guo, Yuewei,Huang, Hui,et al. Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis[J]. ACTA PHARMACEUTICA SINICA B,2018,8(6):944, 955. |
| APA | Ye, Fei,Guo, Yuewei,Huang, Hui,Mao, Shuichun,Li, Songwei,&Zhu, Zhengdan.(2018).Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis.ACTA PHARMACEUTICA SINICA B,8(6),944. |
| MLA | Ye, Fei,et al."Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis".ACTA PHARMACEUTICA SINICA B 8.6(2018):944. |
入库方式： OAI收割
来源：南海海洋研究所
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