Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster
文献类型:期刊论文
作者 | Zhang, Hua; Huang, Xian-De; Dai, Jia-ge; Lin, Ke-tao; Liu, Mei; Ruan, Hui-ting; Liu, Wen-guang; He, Mao-Xian; Zhao, Mi3 |
刊名 | FISH & SHELLFISH IMMUNOLOGY
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出版日期 | 2018 |
卷号 | 81页码:108 |
关键词 | Pearl oyster lncIRF-2 PfIL-17 RNA interference Nucleus grafting |
ISSN号 | 1050-4648 |
英文摘要 | Long noncoding RNAs (lncRNAs), once thought to be nonfunctional, have recently been shown to participate in the multilevel regulation of transcriptional, posttranscriptional and epigenetic modifications and to play important roles in various biological processes, including immune responses. However, the expression and roles of lncRNAs in invertebrates, especially nonmodel organisms, remain poorly understood. In this study, by comparing a transcriptome to the PfIRF-2 genomic structure, we identified lncIRF-2 in the PfIRF-2 genomic intron. The results of the RNA interference (RNAi) and the nucleus grafting experiments indicated that PfIRF-2 might have a negative regulatory effect on lncIRF-2, and PfIRF-2 and lncIRF-2 may have a positive regulatory effect on PfIL-17. Additionally, lncIRF-2, PfIRF-2 and PfIL-17 were involved in responses to the nucleus graft. These results will enhance the knowledge of lncIRF-2, IRF-2, and IL-17 functions in both pearl oysters and other invertebrates. |
源URL | [http://ir.scsio.ac.cn/handle/344004/17630] ![]() |
专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
作者单位 | 1.Liu, Wen-guang 2.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Prov Key Lab Appl Marine Biol, South China Sea Inst Oceanol, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 3.He, Mao-Xian 4.[Huang, Xian-De 5.Dai, Jia-ge 6.Lin, Ke-tao 7.Liu, Mei 8.South China Agr Univ, Coll Marine Sci, 483 Wushan Rd, Guangzhou 510642, Guangdong, Peoples R China 9.[Huang, Xian-De 10.Zhang, Hua |
推荐引用方式 GB/T 7714 | Zhang, Hua,Huang, Xian-De,Dai, Jia-ge,et al. Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2018,81:108, 112. |
APA | Zhang, Hua.,Huang, Xian-De.,Dai, Jia-ge.,Lin, Ke-tao.,Liu, Mei.,...&Zhao, Mi.(2018).Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster.FISH & SHELLFISH IMMUNOLOGY,81,108. |
MLA | Zhang, Hua,et al."Regulation of IL-17 by lncRNA of IRF-2 in the pearl oyster".FISH & SHELLFISH IMMUNOLOGY 81(2018):108. |
入库方式: OAI收割
来源:南海海洋研究所
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