New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
文献类型：期刊论文
| 作者 | Yang, Bin2; Pang, Xiaoyan2,3; Cai, Guodi1; Lin, Xiuping2; Salendra, Limbadri2; Zhou, Xuefeng2; Wang, Junjian1; Wang, Junfeng2; Xu, Shihai; Liu, Yonghong2 |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2019 |
| 卷号 | 17期号:7页码:398 |
| 关键词 | sponge-derived fungus Penicillium sp alkaloid X-ray single crystal diffraction antibacterial cytotoxic activity |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md17070398 |
| 英文摘要 | The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1-21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR-ESI-MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 mu M. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 mu g/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 mu g/mL. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17814]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China 2.Jinan Univ, Coll Chem & Mat Sci, Guangzhou 510632, Guangdong, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Materia Med, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China 4.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Bin,Pang, Xiaoyan,Cai, Guodi,et al. New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015[J]. MARINE DRUGS,2019,17(7):398. |
| APA | Yang, Bin.,Pang, Xiaoyan.,Cai, Guodi.,Lin, Xiuping.,Salendra, Limbadri.,...&Liu, Yonghong.(2019).New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015.MARINE DRUGS,17(7),398. |
| MLA | Yang, Bin,et al."New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015".MARINE DRUGS 17.7(2019):398. |
入库方式： OAI收割
来源：南海海洋研究所
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