New pyrone and cyclopentenone derivatives from marine-derived fungus Aspergillus sydowii SCSIO 00305
文献类型：期刊论文
| 作者 | Dong, Jun-De; Amin, Muhammad1; Liang, Xiao1; Ma, Xuan; Qi, Shu-Hua |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 关键词 | Aspergillus sydowii 2-pyrone derivative cyclopentenone derivative mycotoxin toxicity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2019.1629919 |
| 英文摘要 | Two new 2-pyrone derivatives sydowiones A-B (1, 2), one new cyclopentenone derivative sydowione C (3), and one new mycotoxin 6-methoxyl austocystin A (4) along with two known analogues paecilpyrone A (5) and austocystin A (6), were isolated from the marine-derived fungus Aspergillus sydowii SCSIO 00305. The structures of 1-4 were elucidated by extensive spectroscopic analysis. The absolute configuration of C-8 in 1 was established by Mosher method, and further confirmed by calculation of the electronic circular dichroism (ECD) spectra. The absolute configuration of C-11 in 3 was also determined by calculation of ECD spectra. The absolute configuration of 6 was determined by a single-crystal X-ray diffraction experiment for the first time. Compounds 1-4 showed moderate toxicity towards brine shrine naupalii with LC50 values of 19.5, 14.3, 8.3 and 2.9 mu M, respectively. And 1 and 2 also showed antioxidant activity against 2,2-diphenyl-picrylhydrazyl (DPPH) radicals with IC50 values of 46.0 and 46.6 mu M, respectively. [GRAPHICS] . |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17825]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Inst South China Sea Ecol & Environm Engn, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Jun-De,Amin, Muhammad,Liang, Xiao,et al. New pyrone and cyclopentenone derivatives from marine-derived fungus Aspergillus sydowii SCSIO 00305[J]. NATURAL PRODUCT RESEARCH. |
| APA | Dong, Jun-De,Amin, Muhammad,Liang, Xiao,Ma, Xuan,&Qi, Shu-Hua. |
| MLA | Dong, Jun-De,et al."New pyrone and cyclopentenone derivatives from marine-derived fungus Aspergillus sydowii SCSIO 00305".NATURAL PRODUCT RESEARCH |
入库方式： OAI收割
来源：南海海洋研究所
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