Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor alpha
文献类型：期刊论文
| 作者 | Zheng, Zhihui1; Zhang, Xuelian1; Liang, Xiao2; Qi, Shuhua; Ma, Xuan; Lu, Xinhua1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2019 |
| 卷号 | 82期号:6页码:1558 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.9b00055 |
| 英文摘要 | Eight new diketopiperazine-type alkaloids including four oxepin-containing diketopiperazine-type alkaloids, oxepinamides H-K (1-4), and four 4-quinazolinone alkaloids, puniceloids A-D (5-8), together with two known analogues (9 and 10), were isolated from the culture broth extracts of the deep-sea-derived fungus Aspergillus puniceus SCSIO z021. Their structures were elucidated by spectroscopic analyses, and their absolute configurations were determined by Marfey's method along with comparison of their specific rotations and ECD spectra. The absolute configurations of 4 and 5 were further confirmed by a single-crystal X-ray diffraction analysis. Compounds 1-8 showed significant transcriptional activation of liver X receptor alpha with EC50 values of 1.7-50 mu M, and 7 and 8 were the most potent agonists. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17832]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, South China Sea Inst Oceanol, Inst South China Sea Ecol & Environm Engn, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 3.North China Pharmaceut Grp Corp, New Drug Res & Dev Co Ltd, Shijiazhuang 050015, Hebei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Zhihui,Zhang, Xuelian,Liang, Xiao,et al. Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor alpha[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(6):1558, 1564. |
| APA | Zheng, Zhihui,Zhang, Xuelian,Liang, Xiao,Qi, Shuhua,Ma, Xuan,&Lu, Xinhua.(2019).Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor alpha.JOURNAL OF NATURAL PRODUCTS,82(6),1558. |
| MLA | Zheng, Zhihui,et al."Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor alpha".JOURNAL OF NATURAL PRODUCTS 82.6(2019):1558. |
入库方式： OAI收割
来源：南海海洋研究所
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