Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301
文献类型：期刊论文
| 作者 | Liu, Nianzhen2; Wang, Junfeng; Liu, Yonghong4; Zhou, Xiaojiang2; Zhou, Xuefeng; Yang, Bin; Liao, Shengrong; Lin, Xiuping; Cong, Ziwen; Yang, Jie3 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2019 |
| 卷号 | 135页码:27 |
| 关键词 | Aspergillus sydowii Sesquiterpenoid Xanthone Antiviral activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2019.03.031 |
| 英文摘要 | Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6-19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1-3, and 6-19) were evaluated for their antiviral, cytotoxic, and antibacterial activities. Among them, new compounds 2 and 3 displayed obvious selective inhibitory activities against two influenza A virus subtypes, including A/Puerto Rico/8/34 (H1N1) and A/FM-1/1/47 (H1N1), with IC50 values ranging from 2.17 +/- 1.39 to 4.70 +/- 1.11 mu M. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17836]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China 3.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 4.Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging VirusPrevent, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Nianzhen,Wang, Junfeng,Liu, Yonghong,et al. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301[J]. FITOTERAPIA,2019,135:27, 32. |
| APA | Liu, Nianzhen.,Wang, Junfeng.,Liu, Yonghong.,Zhou, Xiaojiang.,Zhou, Xuefeng.,...&Peng, Shuai.(2019).Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301.FITOTERAPIA,135,27. |
| MLA | Liu, Nianzhen,et al."Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSI041301".FITOTERAPIA 135(2019):27. |
入库方式： OAI收割
来源：南海海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。