Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017
文献类型：期刊论文
| 作者 | Salendra, Limbadri2; Lin, Xiuping; Chen, Weihao2; Pang, Xiaoyan3; Luo, Xiaowei2; Long, Jieyi2; Liao, Shengrong; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong1,2 |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 关键词 | Sponge-associated fungus Penicillium citrinum SCSIO 41017 polyketides steroids cytotoxicity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2019.1610757 |
| 英文摘要 | Two new polyketides, xerucitrinin A (1) and coniochaetone M (8), and one new steroid, 16 alpha-methylpregna-17 alpha,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (13), together with eleven known analogues were isolated from fungus Penicillium citrinum SCSIO 41017 associated with the sponge Callyspongia sp. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data. Biological evaluation results revealed that 5 exhibited significant cytotoxic activity against MCF-7 cell line with IC50 values of 1.3 mu M. Compound 13 showed moderate activity against all cell lines with IC50 values of 13.5-18.0 mu M, and compounds 9 and 14 showed weak activity with MIC values of ranging from 125 mu g/mL to 250 mu g/mL respectively. [GRAPHICS] . |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17837]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Jinan Univ, Coll Chem & Mat Sci, Dept Chem, Guangzhou, Guangdong, Peoples R China 2.Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,Res Ctr Marine Micro, Guangzhou 510301, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst South China Sea Ecol & Environm Engn, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Salendra, Limbadri,Lin, Xiuping,Chen, Weihao,et al. Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017[J]. NATURAL PRODUCT RESEARCH. |
| APA | Salendra, Limbadri.,Lin, Xiuping.,Chen, Weihao.,Pang, Xiaoyan.,Luo, Xiaowei.,...&Yang, Bin. |
| MLA | Salendra, Limbadri,et al."Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus Penicillium citrinum SCSIO 41017".NATURAL PRODUCT RESEARCH |
入库方式： OAI收割
来源：南海海洋研究所
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