Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent
文献类型：期刊论文
| 作者 | Liu, Juan1; Yang, Bin1; Tan, Suiyi; Zhou, Xuefeng1; Liu, Yonghong1; Xun, Tianrong |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2019 |
| 卷号 | 33期号:10页码:1467 |
| 关键词 | Penicillixanthone A anti-HIV-1 CCR5 CXCR4 marine fungi |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2017.1416376 |
| 英文摘要 | Marine micro-organisms have been proven to be excellent sources of bioactive compounds against HIV-1. Several natural products obtained from marine-derived Aspergillus fungi were screened for their activities to inhibit HIV-1 infection. Penicillixanthone A (PXA), a natural xanthone dimer from jellyfish-derived fungus Aspergillus fumigates, displayed potent anti-HIV-1 activity by inhibiting infection against CCR5-tropic HIV-1 SF162 and CXCR4-tropic HIV-1 NL4-3, with IC50 of 0.36 and 0.26 mu M, respectively. Molecular docking study was conducted to understand the possible binding mode of PXA with the CCR5/CXCR4. The results revealed that, the marine-derived PXA, as a CCR5/CXCR4 dual-coreceptor antagonist, presents a new type of potential lead product for the development of anti-HIV therapeutics. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17845]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.South Med Univ, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangdong Prov Key Lab New Drug Screening, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China 2.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Key Lab Trop Marine Bioresources & Ecol, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Juan,Yang, Bin,Tan, Suiyi,et al. Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent[J]. NATURAL PRODUCT RESEARCH,2019,33(10):1467, 1471. |
| APA | Liu, Juan,Yang, Bin,Tan, Suiyi,Zhou, Xuefeng,Liu, Yonghong,&Xun, Tianrong.(2019).Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent.NATURAL PRODUCT RESEARCH,33(10),1467. |
| MLA | Liu, Juan,et al."Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent".NATURAL PRODUCT RESEARCH 33.10(2019):1467. |
入库方式： OAI收割
来源：南海海洋研究所
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