Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster
文献类型：期刊论文
| 作者 | Fang, Zhuangjie1; Ma, Liang; Zhang, Changsheng1; Zhu, Yiguang; Zhang, Wenjun; Yang, Chunfang; Huang, Chunshuai1 |
| 刊名 | JOURNAL OF ANTIBIOTICS
 |
| 出版日期 | 2019 |
| 卷号 | 72期号:5页码:311 |
| ISSN号 | 0021-8820 |
| DOI | 10.1038/s41429-019-0161-4 |
| 英文摘要 | Heterologous expression of the fluostatin biosynthetic gene cluster from the marine-derived Micromonospora rosaria SCSIO N160 in Streptomyces albus J1074 led to the isolation of a novel isoindolequinone albumycin (1) and a known isoquinolinequinone mansouramycin A (2). The structure of 1 was elucidated on the basis of detailed 1D and 2D NMR spectroscopic analysis. Mansouramycin A (2) is active against methicillin-resistant Staphylococcus aureus ATCC 43300, with a MIC of 8 mu g ml(-1), while albumycin (1) displayed negligible antibacterial activities. This study represents another example of activation of secondary metabolites that are non-relevant to the heterologously introduced biosynthetic gene cluster in a bacterial host. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17855]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,South China Sea, RNAM Ctr Marine Microbiol,Inst South China Sea Ec, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Zhuangjie,Ma, Liang,Zhang, Changsheng,et al. Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster[J]. JOURNAL OF ANTIBIOTICS,2019,72(5):311, 315. |
| APA | Fang, Zhuangjie.,Ma, Liang.,Zhang, Changsheng.,Zhu, Yiguang.,Zhang, Wenjun.,...&Huang, Chunshuai.(2019).Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster.JOURNAL OF ANTIBIOTICS,72(5),311. |
| MLA | Fang, Zhuangjie,et al."Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster".JOURNAL OF ANTIBIOTICS 72.5(2019):311. |
入库方式： OAI收割
来源：南海海洋研究所
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