Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain
文献类型：期刊论文
| 作者 | Liu, Zhiyong3; Shao, Mingwei2; Ma, Junying2; Wei, Xiaoyi4; Zhang, Tianyu3,5; Li, Wenjun1; Ju, Jianhua2,5; Liu, Qing1,2; Sun, Changli2 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019 |
| 卷号 | 21期号:8页码:2634 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b00618 |
| 英文摘要 | Atrovimycin (1), a cyclodepsipeptide containing a unique vicinal-hydroxylated cinnamic acyl chain, was isolated and elucidated from Streptomyces atrovirens LQ13. The biosynthetic pathway of 1 was achieved, revealing cytochrome P450 (Avm43) and epoxide hydrolase (Avm29) enzymes constructing the vicinal-dihydroxy substitution, as well as a tailoring P450 (Avm28) enzyme catalyzing beta-hydroxylation of the L-Phe moiety. Atrovimycin shows in vitro antifungal activity and antitubercular activity against Mycobacterium tuberculosis H37Rv both in vitro (with MIC of 2.5 mu g/mL) and in vivo. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17860]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Plant Resources, Guangzhou 510275, Guangdong, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China 4.Chinese Acad Sci, GIBH, Guangzhou Regenerat Med & Hlth Guangdong Lab GRMH, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China 5.Chinese Acad Sci, South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China 6.Univ Chinese Acad Sci, Beijing 110039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhiyong,Shao, Mingwei,Ma, Junying,et al. Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain[J]. ORGANIC LETTERS,2019,21(8):2634, 2638. |
| APA | Liu, Zhiyong.,Shao, Mingwei.,Ma, Junying.,Wei, Xiaoyi.,Zhang, Tianyu.,...&Sun, Changli.(2019).Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain.ORGANIC LETTERS,21(8),2634. |
| MLA | Liu, Zhiyong,et al."Discovery and Biosynthesis of Atrovimycin, an Antitubercular and Antifungal Cyclodepsipeptide Featuring Vicinal-dihydroxylated Cinnamic Acyl Chain".ORGANIC LETTERS 21.8(2019):2634. |
入库方式： OAI收割
来源：南海海洋研究所
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