Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster
文献类型：期刊论文
| 作者 | Zhang, Chunyan2; Sun, Changli; Yang, Zhijie2; Liu, Zhiyong1; He, Jianqiao2; Liu, Qing3,4; Zhang, Tianyu1,2; Ju, Jianhua2; Ma, Junying |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019 |
| 卷号 | 21期号:5页码:1453 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b00208 |
| 英文摘要 | Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin's structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data, and Marfey's method; a plausible biosynthesis and tailoring modification of 1 are also proposed and investigated. Additionally, atratumycin is active against Mycobacteria tuberculosis H37Ra and H37Rv with MICs of 3.8 and 14.6 mu M, respectively. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17884]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou 510301, Guangdong, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, TB Res Lab, Guangzhou 510530, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 4.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China 5.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Plant Resources, Guangzhou 510275, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Chunyan,Sun, Changli,Yang, Zhijie,et al. Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster[J]. ORGANIC LETTERS,2019,21(5):1453, 1457. |
| APA | Zhang, Chunyan.,Sun, Changli.,Yang, Zhijie.,Liu, Zhiyong.,He, Jianqiao.,...&Ma, Junying.(2019).Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster.ORGANIC LETTERS,21(5),1453. |
| MLA | Zhang, Chunyan,et al."Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster".ORGANIC LETTERS 21.5(2019):1453. |
入库方式： OAI收割
来源：南海海洋研究所
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