Effects of antimicrobial peptides on serum biochemical parameters, antioxidant activity and non-specific immune responses in Epinephelus coioides
文献类型：期刊论文
| 作者 | Sun, Hong-Yan; Dan, Xue-Ming; Su, Yu-Ling; Chen, Guo; Chen, Liang-Shi; Li, Jia-Zhou; Wang, Gang; He, Jia-Yang; Zhan, Tian-Yong; Li, Yan-Wei |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2019 |
| 卷号 | 86页码:1081 |
| 关键词 | Epinephelus coioides Antimicrobial peptides Blood biochemical parameters Antioxidant Immunity Immune-related genes |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2018.12.056 |
| 英文摘要 | Antimicrobial peptides (AMPs) are small proteins showing broad-spectrum antimicrobial activity that have been known to be powerful agents against a variety of pathogens (bacteria, fungi and viruses). In this study, the effects of AMPs from Bacillus subtilis on Epinephelus coioides were examined. E. coioides were fed with diets containing AMPs (0, 100, 200, 400 or 800 mg/kg) for four weeks. Results showed that the levels of total protein (TP), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and blood glucose (GLU) and lipopolysaccharide (LPS) in the serum of E. coioides changed than those of the control group; compared to the control group, the levels of total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and lysozyme (LZM) levels in E. coioides fed with different dosages AMP diets were also different; in addition, the mRNA expression of tumor necrosis factor alpha (TNF-alpha), interleukin-1-beta (IL-1 beta), and heat shock protein 90 (Hsp90) in the tissues of E. coioides were measured, the three genes in the tissues examined were significantly upregulated. The results demonstrated that diets containing AMPs can enhance the antioxidant capacity and innate immune ability of E. coioides, indicating that AMPs might be a potential alternative to antibiotics in E. coioides. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17887]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Su, Yu-Ling 2.Chen, Guo 3.Chen, Liang-Shi 4.Wang, Gang 5.He, Jia-Yang 6.Zhan, Tian-Yong 7.Li, Yan-Wei 8.Yan, Mu-Ting 9.Huang, You-Hua 10.Qin, Qi-Wei |
| 推荐引用方式 GB/T 7714 | Sun, Hong-Yan,Dan, Xue-Ming,Su, Yu-Ling,et al. Effects of antimicrobial peptides on serum biochemical parameters, antioxidant activity and non-specific immune responses in Epinephelus coioides[J]. FISH & SHELLFISH IMMUNOLOGY,2019,86:1081, 1087. |
| APA | Sun, Hong-Yan.,Dan, Xue-Ming.,Su, Yu-Ling.,Chen, Guo.,Chen, Liang-Shi.,...&Qin, Qi-Wei.(2019).Effects of antimicrobial peptides on serum biochemical parameters, antioxidant activity and non-specific immune responses in Epinephelus coioides.FISH & SHELLFISH IMMUNOLOGY,86,1081. |
| MLA | Sun, Hong-Yan,et al."Effects of antimicrobial peptides on serum biochemical parameters, antioxidant activity and non-specific immune responses in Epinephelus coioides".FISH & SHELLFISH IMMUNOLOGY 86(2019):1081. |
入库方式： OAI收割
来源：南海海洋研究所
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