Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field
文献类型：期刊论文
| 作者 | Liu, Yonghong; Lin, Xiuping; Li, Kunlong1; Yang, Lilin3; Peng, Xiaoying4; Fang, Wei2; Tian, Xinpeng; Zhou, Xuefeng |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2019 |
| 卷号 | 33期号:4页码:494 |
| 关键词 | Hydrothermal bacteria dereplication targeted isolation antivirus butyrolactone I 3-sulphate |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2017.1399382 |
| 英文摘要 | Marine micro-organisms in the deep-sea hydrothermal vent systems are considered as potential sources of bioactive natural products. Sixteen bacterial strains were isolated from a deep-sea hydrothermal field and screened for bioactive metabolism studies. After the strains were subjected to bioactive testing at different culture media, chemical dereplication by HPLC coupled to high-resolution mass spectrometer was performed to analyse or determine the main secondary metabolisms in those strains. Strain 06204 was large-scale fermented with relative optimal media, for isolating the desired sulphur compound. Butyrolactone I 3-sulphate was isolated and structurally identified from the extract, guided by dereplication and showed moderate antivirus activities against H3N2 and EV71 viruses. Our study suggests that deep-sea hydrothermal bacteria are good sources of sulphur natural products. Meanwhile, the described approach, mainly bioactive screening, dereplication and targeted isolation, is effective and efficient to discover interesting bioactive compounds in hydrothermal bacteria. [GRAPHICS] . |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17898]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Guangdong Key Lab Marine Materia Med, Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol,RNAM Ctr Marine Micr, Guangzhou, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing, Peoples R China 3.Hubei Acad Agr Sci, Hubei Biopesticide Engn Res Ctr, Wuhan, Hubei, Peoples R China 4.Guangzhou 6 Middle Sch, Guangzhou, Guangdong, Peoples R China 5.Shenzhen Univ, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yonghong,Lin, Xiuping,Li, Kunlong,et al. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field[J]. NATURAL PRODUCT RESEARCH,2019,33(4):494, 499. |
| APA | Liu, Yonghong.,Lin, Xiuping.,Li, Kunlong.,Yang, Lilin.,Peng, Xiaoying.,...&Zhou, Xuefeng.(2019).Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field.NATURAL PRODUCT RESEARCH,33(4),494. |
| MLA | Liu, Yonghong,et al."Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field".NATURAL PRODUCT RESEARCH 33.4(2019):494. |
入库方式： OAI收割
来源：南海海洋研究所
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