Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers
文献类型：期刊论文
| 作者 | Zhang, Weimin1; Zhang, Liping; Liu, Zhiwen; Ma, Liang; Zhang, Wenjun; Zhu, Yiguang; Chen, Yuchan1; Zhang, Changsheng |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2019 |
| 卷号 | 17期号:5页码:1053 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c8ob02775g |
| 英文摘要 | The halogenase gene spmH was putatively involved in the biosynthesis of spiroindimicins/indimicins (SPMs/IDMs), a group of chlorinated tryptophan dimers (TDs) from deep-sea-derived Streptomyces sp. SCSIO 03032. Inactivation of spmH led to six deschloro-analogues of TDs, including four new compounds SPMs G (1) and H (2), and IDMs F (3) and G (4). The structures and absolute configurations of 1-4 were unambiguously determined by the combination of extensive spectroscopic analysis, single-crystal X-ray diffraction and quantum chemical ECD calculations. Compounds 1 and 2 exhibited moderate cytotoxic activities against four cancer cell lines. Additionally, SpmH was biochemically characterized in vitro as an L-tryptophan 5-halogenase. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17899]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, Key Lab Trop Marine Bioresources & Ecol, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China 2.Guangdong Inst Microbiol, State Key Lab Appl Microbiol Southern China, 100 Cent Xianlie Rd, Guangzhou 510070, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Weimin,Zhang, Liping,Liu, Zhiwen,et al. Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2019,17(5):1053, 1057. |
| APA | Zhang, Weimin.,Zhang, Liping.,Liu, Zhiwen.,Ma, Liang.,Zhang, Wenjun.,...&Zhang, Changsheng.(2019).Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers.ORGANIC & BIOMOLECULAR CHEMISTRY,17(5),1053. |
| MLA | Zhang, Weimin,et al."Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers".ORGANIC & BIOMOLECULAR CHEMISTRY 17.5(2019):1053. |
入库方式： OAI收割
来源：南海海洋研究所
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