中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus

文献类型:期刊论文

作者Xue, Jiao; Qu, Xudong; Hu, Yunfeng2; Deng, Zixin; Bi, Hongkai1; Qiao, Yongjian; Yan, Jiayan; Jia, Jia1; Zhu, Dongqing
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2019
卷号82期号:2页码:318
ISSN号0163-3864
DOI10.1021/acs.jnatprod.8b00753
英文摘要Armeniaspirols (1-3) are potent antibiotics against Gram-positive pathogens. Through a biosynthetic investigation, we identified four enzymes involved in the structural modification of 1-3. Manipulation of their activity led to the generation of 4-6 and nine novel analogues, 7-15. Bioactivity assessments revealed that the pyrrole chloro group and the methyl group are important for the antimicrobial activities of armeniaspirols, which lays the foundation for future structure optimization and mechanism of action studies of armeniaspirols.
源URL[http://ir.scsio.ac.cn/handle/344004/17906]  
专题南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
作者单位1.Wuhan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Hubei, Peoples R China
2.Nanjing Med Univ, Dept Pathogen Biol, Nanjing 210029, Jiangsu, Peoples R China
3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China
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Xue, Jiao,Qu, Xudong,Hu, Yunfeng,et al. Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(2):318, 323.
APA Xue, Jiao.,Qu, Xudong.,Hu, Yunfeng.,Deng, Zixin.,Bi, Hongkai.,...&Zhu, Dongqing.(2019).Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.JOURNAL OF NATURAL PRODUCTS,82(2),318.
MLA Xue, Jiao,et al."Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus".JOURNAL OF NATURAL PRODUCTS 82.2(2019):318.

入库方式: OAI收割

来源:南海海洋研究所

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