Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus
文献类型：期刊论文
| 作者 | Xue, Jiao; Qu, Xudong; Hu, Yunfeng2; Deng, Zixin; Bi, Hongkai1; Qiao, Yongjian; Yan, Jiayan; Jia, Jia1; Zhu, Dongqing |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2019 |
| 卷号 | 82期号:2页码:318 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.8b00753 |
| 英文摘要 | Armeniaspirols (1-3) are potent antibiotics against Gram-positive pathogens. Through a biosynthetic investigation, we identified four enzymes involved in the structural modification of 1-3. Manipulation of their activity led to the generation of 4-6 and nine novel analogues, 7-15. Bioactivity assessments revealed that the pyrrole chloro group and the methyl group are important for the antimicrobial activities of armeniaspirols, which lays the foundation for future structure optimization and mechanism of action studies of armeniaspirols. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17906]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Wuhan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Hubei, Peoples R China 2.Nanjing Med Univ, Dept Pathogen Biol, Nanjing 210029, Jiangsu, Peoples R China 3.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Jiao,Qu, Xudong,Hu, Yunfeng,et al. Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(2):318, 323. |
| APA | Xue, Jiao.,Qu, Xudong.,Hu, Yunfeng.,Deng, Zixin.,Bi, Hongkai.,...&Zhu, Dongqing.(2019).Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus.JOURNAL OF NATURAL PRODUCTS,82(2),318. |
| MLA | Xue, Jiao,et al."Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus".JOURNAL OF NATURAL PRODUCTS 82.2(2019):318. |
入库方式： OAI收割
来源：南海海洋研究所
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