Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008
文献类型：期刊论文
| 作者 | Lu Yong-Jun; Liu Yong-Hong; Luo Xiao-Wei; Lin Yun; Zhou Xue-Feng |
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2019 |
| 卷号 | 17期号:2页码:149 |
| 关键词 | Aspergillus terreus Aspergillamides Polyketides MptpB inhibitor |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(19)30017-2 |
| 英文摘要 | Two new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC50 being 5.11 +/- 0.53 mu mol.L-1, and acted as a noncompetitive inhibitor based on kinetic analysis. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17910]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Luo Xiao-Wei 2.Sun Yat Sen Univ, Biomed Ctr, Guangzhou 510275, Guangdong, Peoples R China 3.[Lin Yun 4.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China 5.[Lin Yun 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Zhou Xue-Feng 8.[Luo Xiao-Wei 9.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China 10.Zhou Xue-Feng |
| 推荐引用方式 GB/T 7714 | Lu Yong-Jun,Liu Yong-Hong,Luo Xiao-Wei,et al. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(2):149, 154. |
| APA | Lu Yong-Jun,Liu Yong-Hong,Luo Xiao-Wei,Lin Yun,&Zhou Xue-Feng.(2019).Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008.CHINESE JOURNAL OF NATURAL MEDICINES,17(2),149. |
| MLA | Lu Yong-Jun,et al."Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008".CHINESE JOURNAL OF NATURAL MEDICINES 17.2(2019):149. |
入库方式： OAI收割
来源：南海海洋研究所
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