Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium
文献类型：期刊论文
| 作者 | Zhao, Biqing; Zhou, Xiaojiang; Liu, Yonghong2; Zhong, Zhenping4; Cai, Liang3; Qin, Li; Wang, Junfeng2 |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2019 |
| 卷号 | 17期号:1页码:195 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c8ob02519c |
| 英文摘要 | Crotonols A and B (1 and 2), two tigliane diterpenoids featuring a rare C-7/C-14 cyclized and novel 5/7/7-fused carbon skeleton, along with the known tigliane wallichiioid A, were isolated from the leaves of Croton tiglium. Their structures were determined through spectroscopic methods, X-ray crystallography and ECD analysis. To the best of our knowledge, crotonol B (2) represents the first example of 13,14-seco-tigliane diterpenoids. Crotonols A and B displayed strong cytotoxic activities against the K562 cell line with IC50 values of 0.20 and 0.21 M, respectively. Furthermore, crotonol A promoted the apoptosis of K562 cells through the cleavage of PARP and the accumulation of bax as well as the degradation of bcl-2. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17919]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Yao Sheng Tang Hu Nan Pharmaceut Co Ltd, Anxiang 415600, Peoples R China 2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China 4.Hunan Prov Ctr Dis Control & Prevent, Changsha 410005, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Biqing,Zhou, Xiaojiang,Liu, Yonghong,et al. Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2019,17(1):195, 202. |
| APA | Zhao, Biqing.,Zhou, Xiaojiang.,Liu, Yonghong.,Zhong, Zhenping.,Cai, Liang.,...&Wang, Junfeng.(2019).Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium.ORGANIC & BIOMOLECULAR CHEMISTRY,17(1),195. |
| MLA | Zhao, Biqing,et al."Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium".ORGANIC & BIOMOLECULAR CHEMISTRY 17.1(2019):195. |
入库方式： OAI收割
来源：南海海洋研究所
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