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A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst
文献类型：期刊论文
| 作者 | Shen, YC ; Feng, XM ; Li, Y ; Zhang, GL ; Jiang, YZ |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2003 |
| 卷号 | 59期号:30页码:5667_5675 |
| 关键词 | Lewis acid Lewis base catalyst cyanosilylation ketone |
| ISSN号 | 0040-4020 |
| 产权排序 | 3 |
| 通讯作者 | Feng, XM, Sichuan Univ, Coll Chem, Sichuan Key LGreen Chem & Technol, Chengdu 610064, Peoples R China. |
| 中文摘要 | A new family of bifunctional catalysts (N-oxides-Ti((OPr)-Pr-i)(4) (2: 1)) containing a Lewis acid and a Lewis base was developed and applied to the catalytic cyanosilylation of ketones. Utilizing rac((1R,2S) and (1S,2R))-1-(2'-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide-titanium (2: 1) complex and N-benzyl-diethanolamine N-oxide-titanium (2: 1) complex as catalysts, the cyanosilylation products were obtained in 42-97% yield. Based on experimental phenomena and kinetic studies, a catalytic cycle was proposed to explain the remarkable activities of these catalysts. Investigations indicated that rac((1R,2S) and (1S,2R))-1-(2'-pyridylmethyl)-2-diphenylhydroxy-methylpyrrolidine N-oxide-titanium (2:1) complex and N-benzyl-diethanolamine N-oxide-titanium (2:1) complex should promote the reaction via a dual activation of the ketone by the titanium and TMSCN by the N-oxide. (C) 2003 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry, Organic |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000184306000005 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/17373]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 推荐引用方式 GB/T 7714 | Shen, YC,Feng, XM,Li, Y,et al. A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst[J]. TETRAHEDRON,2003,59(30):5667_5675. |
| APA | Shen, YC,Feng, XM,Li, Y,Zhang, GL,&Jiang, YZ.(2003).A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst.TETRAHEDRON,59(30),5667_5675. |
| MLA | Shen, YC,et al."A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst".TETRAHEDRON 59.30(2003):5667_5675. |
入库方式： OAI收割
来源：成都生物研究所
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