Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399
文献类型：期刊论文
| 作者 | Cong, Ziwen1; Wang, Junfeng; Huang, Dongyi1; Zhou, Xuefeng; Yang, Bin; Liao, Shengrong; Wang, Pei2; Liu, Yuxuan; Liu, Yunhao; Huang, Xiaolong1 |
| 刊名 | JOURNAL OF ANTIBIOTICS
 |
| 出版日期 | 2019 |
| 卷号 | 72期号:1页码:45 |
| ISSN号 | 0021-8820 |
| DOI | 10.1038/s41429-018-0103-6 |
| 英文摘要 | Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 mu M, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC(50 )values of 22.0 +/- 0.20, 1.80 +/- 0.01 and 12.1 +/- 0.07 mu M, respectively. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17929]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China 2.Hainan Univ, Inst Trop Agr & Forestry, Haikou 570228, Hainan, Peoples R China 3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, Haikou 571101, Hainan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cong, Ziwen,Wang, Junfeng,Huang, Dongyi,et al. Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399[J]. JOURNAL OF ANTIBIOTICS,2019,72(1):45, 49. |
| APA | Cong, Ziwen.,Wang, Junfeng.,Huang, Dongyi.,Zhou, Xuefeng.,Yang, Bin.,...&Huang, Xiaolong.(2019).Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399.JOURNAL OF ANTIBIOTICS,72(1),45. |
| MLA | Cong, Ziwen,et al."Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399".JOURNAL OF ANTIBIOTICS 72.1(2019):45. |
入库方式： OAI收割
来源：南海海洋研究所
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