Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling
文献类型：期刊论文
| 作者 | Chen, Guozhu2; Guo, Zhengyan; Li, Pengwei; Ju, Jianhua1; Chen, Yihua3; Lin, Shuangjun5; Xiang, Hua3; Ren, Jinwei4; Zhang, Yuwei3; Cao, Zhenju3 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2018 |
| 卷号 | 140期号:51页码:18009 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/jacs.8b10136 |
| 英文摘要 | Alboflavusins (AFNs) are a group of cyclo-hexapeptides with moderate antibacterial and antitumor activities from Streptomyces alboflavus sp. 313. In vivo and in vitro studies proposed that AFNs are biosynthesized by a nonribosomal peptide synthetase machinery, and the 6-Cl-L-Trp precursor is supplied by a tryptophan halogenase gene located outside the afn gene cluster. Guided by the structure-activity relationship knowledge about the AFN-like cyclo-hexapeptides, two dimeric AFNs (di-AFNs) with regiospecific biaryl linkages were designed and generated biotechnologically by expressing the P450 gene hmtS or clpS in S. alboflavus wild-type and mutant strains. The di-AFNs displayed much better antibacterial and antitumor activities than their monomers as anticipated, exemplifying a rational strategy to generate natural product congeners with improved bioactivities. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17930]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Sch Life Sci & Biotechnol, Shanghai 200030, Peoples R China 2.Chinese Acad Sci, State Key Lab Microbial Resources, Inst Microbiol, Beijing 100101, Peoples R China 3.Acad Mil Med Sci, Inst Mil Cognit & Brain Sci, Beijing 100850, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, State Key Lab Mycol, Inst Microbiol, Beijing 100101, Peoples R China 6.Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guozhu,Guo, Zhengyan,Li, Pengwei,et al. Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2018,140(51):18009, 18015. |
| APA | Chen, Guozhu.,Guo, Zhengyan.,Li, Pengwei.,Ju, Jianhua.,Chen, Yihua.,...&Li, Chao.(2018).Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,140(51),18009. |
| MLA | Chen, Guozhu,et al."Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-C Bond Coupling".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140.51(2018):18009. |
入库方式： OAI收割
来源：南海海洋研究所
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