Spirostaphylotrichin X from a Marine-Derived Fungus as an Anti-influenza Agent Targeting RNA Polymerase PB2
文献类型：期刊论文
| 作者 | Wang, Jianjiao3; Liu, Yuxuan1; Li, Kunlong; Yang, Xiliang4; Liu, Shuwen2,5; Chen, Feimin2; Zhou, Xuefeng5; Yang, Jie2; Liu, Yunhao1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2018 |
| 卷号 | 81期号:12页码:2722 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.8b00656 |
| 英文摘要 | A new spirocyclic gamma-lactam, named spirostaphylotrichin X (1), and three related known spirostaphylotrichins (2-4) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures were determined by spectroscopic analyses. Spirostaphylotrichin X (1) displayed obvious inhibitory activities against multiple influenza virus strains, with IC50 values from 1.2 to 5.5 mu M. Investigation of the mechanism showed that 1 inhibited viral polymerase activity and interfered with the production of progeny viral RNA. Homogeneous time-resolved fluorescence, surface plasmon resonance assays, and a molecular docking study revealed that 1 could inhibit polymerase PB2 protein activity by binding to the highly conserved region of the cap-binding domain of PB2. These results suggest that 1 inhibits the replication of influenza A virus by interfering with the activity of PB2 protein and that 1 represents a new type of potential lead compound for the development of anti-influenza therapeutics. |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/17932]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.Southern Med Univ, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China 2.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Materia Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China 3.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Wuhan Univ Sci & Technol, Med Coll, Dept Pharm, Wuhan 430065, Hubei, Peoples R China 6.Sun Yat Sen Univ, Middle Sch, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jianjiao,Liu, Yuxuan,Li, Kunlong,et al. Spirostaphylotrichin X from a Marine-Derived Fungus as an Anti-influenza Agent Targeting RNA Polymerase PB2[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(12):2722, 2730. |
| APA | Wang, Jianjiao.,Liu, Yuxuan.,Li, Kunlong.,Yang, Xiliang.,Liu, Shuwen.,...&Liu, Yunhao.(2018).Spirostaphylotrichin X from a Marine-Derived Fungus as an Anti-influenza Agent Targeting RNA Polymerase PB2.JOURNAL OF NATURAL PRODUCTS,81(12),2722. |
| MLA | Wang, Jianjiao,et al."Spirostaphylotrichin X from a Marine-Derived Fungus as an Anti-influenza Agent Targeting RNA Polymerase PB2".JOURNAL OF NATURAL PRODUCTS 81.12(2018):2722. |
入库方式： OAI收割
来源：南海海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。