Bioprospecting for antituberculosis leads from microbial metabolites
文献类型：期刊论文
| 作者 | Zhang, LX; Guo, H; Song, FH; Dai, HQ; Liu, XY; Fu, CZ; Ashforth, EJ; zhanglixin@im.ac.cn |
| 刊名 | NATURAL PRODUCT REPORTS
 |
| 出版日期 | 2010 |
| 卷号 | 27期号:11页码:1709-1719 |
| ISSN号 | 0265-0568 |
| 英文摘要 | Microbial metabolites have been an important source of tuberculosis (TB) therapeutics, but the last truly novel drug that was approved for the treatment of TB was discovered 40 years ago. In light of the growing threat of multi-drug resistance, recent advances have been made to accelerate the discovery rate of novel TB drugs including diversifying strategies for environmental strains, and high-throughput screening assays. This review will discuss the approaches used in biodiversity- and taxonomy-guided microbial natural product library construction, specific cell-based and target-based high-throughput screening assays and early-stage dereplication processes by liquid chromatography-mass spectrometry (LC-MS). New antituberculosis natural products that have been recently discovered are highlighted. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| URL标识 | 查看原文 |
| 资助项目 | LMB |
| WOS记录号 | WOS:000283312100008 |
| 公开日期 | 2011-07-02 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/3742]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | zhanglixin@im.ac.cn |
| 推荐引用方式 GB/T 7714 | Zhang, LX,Guo, H,Song, FH,et al. Bioprospecting for antituberculosis leads from microbial metabolites[J]. NATURAL PRODUCT REPORTS,2010,27(11):1709-1719. |
| APA | Zhang, LX.,Guo, H.,Song, FH.,Dai, HQ.,Liu, XY.,...&zhanglixin@im.ac.cn.(2010).Bioprospecting for antituberculosis leads from microbial metabolites.NATURAL PRODUCT REPORTS,27(11),1709-1719. |
| MLA | Zhang, LX,et al."Bioprospecting for antituberculosis leads from microbial metabolites".NATURAL PRODUCT REPORTS 27.11(2010):1709-1719. |
入库方式： OAI收割
来源：南海海洋研究所
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