Bioprospecting microbial natural product libraries from the marine environment for drug discovery
文献类型：期刊论文
| 作者 | Ren, BA; Liu, M; Dai, HQ; Wang, JA; Zhang, LX; Xie, QO; Song, FH; Liu, XY; Ashforth, E |
| 刊名 | JOURNAL OF ANTIBIOTICS
 |
| 出版日期 | 2010 |
| 卷号 | 63期号:8页码:415-422 |
| 关键词 | Antibiotic Discovery Dereplication Diversity High-throughput Screening Marine Actinomycetes Natural Product Library Systematics |
| ISSN号 | 0021-8820 |
| 英文摘要 | Marine microorganisms are fascinating resources due to their production of novel natural products with antimicrobial activities. Increases in both the number of new chemical entities found and the substantiation of indigenous marine actinobacteria present a fundamental difficulty in the future discovery of novel antimicrobials, namely dereplication of those compounds already discovered. This review will share our experience on the taxonomic-based construction of a highly diversified and low redundant marine microbial natural product library for high-throughput antibiotic screening. We anticipate that libraries such as these can drive the drug discovery process now and in the future. The Journal of Antibiotics (2010) 63, 415-422, doi:10 1038/ja.2010.56; published online 7 July 2010 |
| 学科主题 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| URL标识 | 查看原文 |
| 资助项目 | LMB |
| WOS记录号 | WOS:000281499800003 |
| 公开日期 | 2011-07-02 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/3776]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Ren, BA,Liu, M,Dai, HQ,et al. Bioprospecting microbial natural product libraries from the marine environment for drug discovery[J]. JOURNAL OF ANTIBIOTICS,2010,63(8):415-422. |
| APA | Ren, BA.,Liu, M.,Dai, HQ.,Wang, JA.,Zhang, LX.,...&Ashforth, E.(2010).Bioprospecting microbial natural product libraries from the marine environment for drug discovery.JOURNAL OF ANTIBIOTICS,63(8),415-422. |
| MLA | Ren, BA,et al."Bioprospecting microbial natural product libraries from the marine environment for drug discovery".JOURNAL OF ANTIBIOTICS 63.8(2010):415-422. |
入库方式： OAI收割
来源：南海海洋研究所
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