Staphylococcus aureus promoter-lux reporters for drug discovery
文献类型：期刊论文
| 作者 | Qi, SH; Davies, J; Mesak, LR; Miao, V; Villanueva, I |
| 刊名 | JOURNAL OF ANTIBIOTICS
 |
| 出版日期 | 2010 |
| 卷号 | 63期号:8页码:492-498 |
| 关键词 | Actinomycete Antibiotic Profiling/fingerprint Luciferase Promoter-lux Reporter Staphylococcus Aureus |
| ISSN号 | 0021-8820 |
| 英文摘要 | We describe a collection of antibiotic-activated Staphylococcus aureus promoter-lux reporter strains that can be used to discriminate among antibiotic classes on the basis of their light production response profile. We screened over 400 culture supernatants from previously uncharacterized actinomycetes from soil for the production of aminocoumarin-type compounds and DNA-damaging agents. Novobiocin production was determined in three isolates of Streptomyces, and streptonigrin, a DNA-damaging agent, together with several other bioactive compounds (oxopropaline D and G), was identified from a novel Kitasatospora isolate. This array provides an effective and specific whole-cell approach to search for classes of antimicrobial compounds in unfractionated culture broths. The Journal of Antibiotics (2010) 63, 492-498, doi 10 1038/ja 2010 74, published online 7 July 2010 |
| 学科主题 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| URL标识 | 查看原文 |
| 资助项目 | LMB |
| WOS记录号 | WOS:000281499800013 |
| 公开日期 | 2011-07-02 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/3778]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Qi, SH,Davies, J,Mesak, LR,et al. Staphylococcus aureus promoter-lux reporters for drug discovery[J]. JOURNAL OF ANTIBIOTICS,2010,63(8):492-498. |
| APA | Qi, SH,Davies, J,Mesak, LR,Miao, V,&Villanueva, I.(2010).Staphylococcus aureus promoter-lux reporters for drug discovery.JOURNAL OF ANTIBIOTICS,63(8),492-498. |
| MLA | Qi, SH,et al."Staphylococcus aureus promoter-lux reporters for drug discovery".JOURNAL OF ANTIBIOTICS 63.8(2010):492-498. |
入库方式： OAI收割
来源：南海海洋研究所
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