Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr
文献类型：期刊论文
| 作者 | Yang, XW; Feng, L; Li, SM; Liu, XH; Li, YL; Wu, L; Shen, YH; Tian, JM; Zhang, X; Liu, XR |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 18期号:2页码:744-754 |
| 关键词 | Abies Georgei Orr Pinaceae Diterpenes Abiesadines A-y Nitric Oxide (No) Raw264.7 Macrophages |
| ISSN号 | 0968-0896 |
| 英文摘要 | Twenty-five new (abiesadines A-Y, 1-25) and 29 known (26-54) diterpenes were isolated from the aerial parts of Abies georgei. Abiesadine A ( 1) is a novel 8,14-seco-abietane, while abiesadine B ( 2) is a novel 9,10-seco-abietane. The structures of the new compounds were established on the basis of spectroscopic data analysis. Manool ( 52) showed the strongest effect against LPS-induced NO production in RAW264.7 macrophages with the IC50 value of 11.0 mu g/mL. In another anti-inflammatory assay against TNF alpha-triggered NF-kappa B activity, (12R, 13R)-8,12-epoxy-14-labden-13-ol ( 54) exhibited the strongest effect (IC50 = 8.7 mu g/mL). For antitumor assays, pomiferin A (26) and 8,11,13-abietatriene-7 alpha, 18-diol (29) both showed the most significant activity against LOVO cells (IC50 = 9.2 mu g/mL). While 7-oxocallitrisic acid ( 46) exhibited significant cytotoxicity against QGY-7703 tumor cells (IC50 = 10.2 mu g/mL). Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| URL标识 | 查看原文 |
| 资助项目 | LMB |
| WOS记录号 | WOS:000273613500027 |
| 公开日期 | 2011-07-02 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/3914]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | wdzhangy@hotmail.com |
| 推荐引用方式 GB/T 7714 | Yang, XW,Feng, L,Li, SM,et al. Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2010,18(2):744-754. |
| APA | Yang, XW.,Feng, L.,Li, SM.,Liu, XH.,Li, YL.,...&wdzhangy@hotmail.com.(2010).Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr.BIOORGANIC & MEDICINAL CHEMISTRY,18(2),744-754. |
| MLA | Yang, XW,et al."Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr".BIOORGANIC & MEDICINAL CHEMISTRY 18.2(2010):744-754. |
入库方式： OAI收割
来源：南海海洋研究所
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