Exploring and Exploiting Microbial Diversity through Metagenomics for Natural Product Drug Discovery
文献类型：期刊论文
| 作者 | lixiang@scsio.ac.cn; Wang, GH; Li, X; Guo, J; Dai, SK; Ouyang, YC; Wu, HB; Sun, W |
| 刊名 | CURRENT TOPICS IN MEDICINAL CHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 9期号:16页码:1525-1535 |
| 关键词 | Metagenomics Microbial Diversity Drug Discovery Bacterial Artificial Chromosome |
| ISSN号 | 1568-0266 |
| 英文摘要 | Microorganisms of millions species exist in every corner of the Earth, and form a dynamic genetic reservoir that are not clearly revealed and categorized due to barrier in current cultivation technology. Their applications in biomedical and environmental aspects are more than satisfactory. However, the situation has drastically changed during the turn of the century because of the rapid development of phylogenetic studies based on rRNA sequencing independent of standard laboratory cultivation. More recently, high throughput sequencing technology which enables direct sequencing of community DNA for metagenomic analyses are making a direct impact on our understanding of microbial diversity, ecology, and secondary metabolism. In this review, we highlight some recent progress and innovation on metagenomic research with an emphasis on natural product drug discovery. The rapid path of accumulating decoded metagenomics would be an efficient guide on direct access to the genomes of numerous non-culturable microorganisms for their genomic diversity and associated chemical prosperity for potential medicinal applications. |
| 学科主题 | Chemistry, Medicinal |
| URL标识 | 查看原文 |
| 资助项目 | LMB |
| WOS记录号 | WOS:000272785100003 |
| 公开日期 | 2011-07-03 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/5040]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | lixiang@scsio.ac.cn |
| 推荐引用方式 GB/T 7714 | lixiang@scsio.ac.cn,Wang, GH,Li, X,et al. Exploring and Exploiting Microbial Diversity through Metagenomics for Natural Product Drug Discovery[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2009,9(16):1525-1535. |
| APA | lixiang@scsio.ac.cn.,Wang, GH.,Li, X.,Guo, J.,Dai, SK.,...&Sun, W.(2009).Exploring and Exploiting Microbial Diversity through Metagenomics for Natural Product Drug Discovery.CURRENT TOPICS IN MEDICINAL CHEMISTRY,9(16),1525-1535. |
| MLA | lixiang@scsio.ac.cn,et al."Exploring and Exploiting Microbial Diversity through Metagenomics for Natural Product Drug Discovery".CURRENT TOPICS IN MEDICINAL CHEMISTRY 9.16(2009):1525-1535. |
入库方式： OAI收割
来源：南海海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。