An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells
文献类型：期刊论文
| 作者 | tanglan_tongji@hotmail.com; Zhou, XF; Tang, L; Liu, YH; zhou-xuefeng@hotmail.com |
| 刊名 | LIPIDS
 |
| 出版日期 | 2009 |
| 卷号 | 44期号:8页码:759-763 |
| 关键词 | Soya-cerebrosides Mixture Of Cerebrosides Interleukin-18 Cytotoxicity Peripheral Blood Mononuclear Cells |
| ISSN号 | 0024-4201 |
| 英文摘要 | An isomeric mixture of two cerebrosides, soya-cerebrosides I and II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f., and their structures were identified by spectroscopic (NMR, MS) analysis. In order to determine the immunomodulatory activities of soya-cerebrosides I and II, the effects of the mixture of cerebrosides (MC) on cytotoxicity of human peripheral blood mononuclear cells (PBMC) and the inhibitory activities to lipopolysaccharide (LPS)-induced interleukin (IL)-18 in PBMC were studied. The MC at concentrations of 10 and 1 mu M, without toxicity to PBMC in 24 h, showed obvious inhibitory activity on IL-18 secretion. Because of this effect of modulating the cellular immune response, soya-cerebrosides I and II were considered to be the active substances of this ethno drug. |
| 学科主题 | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| URL标识 | 查看原文 |
| 资助项目 | LMB |
| WOS记录号 | WOS:000268301900009 |
| 公开日期 | 2011-07-03 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/5094]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | tanglan_tongji@hotmail.com; zhou-xuefeng@hotmail.com |
| 推荐引用方式 GB/T 7714 | tanglan_tongji@hotmail.com,Zhou, XF,Tang, L,et al. An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells[J]. LIPIDS,2009,44(8):759-763. |
| APA | tanglan_tongji@hotmail.com,Zhou, XF,Tang, L,Liu, YH,&zhou-xuefeng@hotmail.com.(2009).An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells.LIPIDS,44(8),759-763. |
| MLA | tanglan_tongji@hotmail.com,et al."An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells".LIPIDS 44.8(2009):759-763. |
入库方式： OAI收割
来源：南海海洋研究所
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