Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 degrees C
文献类型：期刊论文
| 作者 | Jia, XP; Feng, JB; fengjb0618@126.com |
| 刊名 | AQUACULTURE
 |
| 出版日期 | 2009 |
| 卷号 | 289期号:40545页码:129-133 |
| 关键词 | Tilapia Florfenicol Pharmacokinetics Distribution Elimination |
| ISSN号 | 0044-8486 |
| 英文摘要 | Pharmacokinetics, tissue distribution and elimination of florfenicol in tilapia weighing about 98 g held in freshwater at 22 degrees C were studied after they were given a single oral dose of 10 mg kg(-1) body weight (b.w.). Five fish per sampling point were examined after treatment. Plasma, muscle, liver, kidney, bile and gill were collected and analysed by high-performance liquid chromatography (HPLC) method. Florfenicol was rapidly absorbed from intestine and distributed extensively to extravascular tissues. The maximum concentrations (C-max) in both plasma and tissues were observed at 12 h (T-max) and the maximum concentrations in the order of magnitude were bile (10.87 mu g g(-1))>kidney (6.89 mu g g(-1))>muscle (6.88 mu g g(-1))>liver (5.87 mu g g(-1))>plasma (4.46 mu g ml(-1))>gill (3.22 mu g g(-1)). The elimination of florfenicol was rapid in plasma, muscle, liver and gill tissue and relatively slow in kidney and bile. The elimination half-lives (T-1/2 beta) in the order of magnitude were bile (36.29 h)>kidney (16.62 h)>gill (15.07 h)>liver (13.94 h)>muscle (10.97 h)>plasma (10.03 h). At 24 h after administration, the drug concentrations in both plasma and tissues remained above the effective treatment concentrations, which can be concluded by comparison with minimal inhibitory concentrations (MICs) as listed in literature, thus florfenicol can be considered as an appropriate treatment for common bacterial infections in fish farming. (C) 2008 Elsevier B.V. All rights reserved. |
| 学科主题 | Fisheries ; Marine & Freshwater Biology |
| URL标识 | 查看原文 |
| 资助项目 | LMB |
| WOS记录号 | WOS:000264942400020 |
| 公开日期 | 2011-07-03 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/5134]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | fengjb0618@126.com |
| 推荐引用方式 GB/T 7714 | Jia, XP,Feng, JB,fengjb0618@126.com. Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 degrees C[J]. AQUACULTURE,2009,289(40545):129-133. |
| APA | Jia, XP,Feng, JB,&fengjb0618@126.com.(2009).Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 degrees C.AQUACULTURE,289(40545),129-133. |
| MLA | Jia, XP,et al."Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus x O. aureus) held in freshwater at 22 degrees C".AQUACULTURE 289.40545(2009):129-133. |
入库方式： OAI收割
来源：南海海洋研究所
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