Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies
文献类型：期刊论文
| 作者 | lssxal@mail.sysu.edu.cn; Fu, YG; Li, YX; Sun, Y; Xu, AL |
| 刊名 | JOURNAL OF MOLECULAR CELL BIOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 4期号:6页码:352-361 |
| 关键词 | Alternative Polyadenylation Genome-wide Profiling Technologies Gene Expression Regulation |
| ISSN号 | 1674-2788 |
| 英文摘要 | Alternative polyadenylation (APA) plays an important role in gene expression by affecting mRNA stability, translation, and translocation in cells. However, genome-wide APA events have only recently been subjected to more systematic analysis with newly developed high-throughput methods. In this review, we focus on the recent technological development of APA analyses on a genome-wide scale, as well as the impact of APA switches on a number of critical biological processes in animals, including cell proliferation, differentiation, and oncogenic transformation. With the highly enlarged scope of genome-wide APA analyses, the APA regulations of various biological processes have increasingly become a new paradigm for the regulation of gene transcription and translation. |
| 学科主题 | Cell Biology |
| 资助项目 | LMB |
| 语种 | 英语 |
| 公开日期 | 2013-08-28 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/9734]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | lssxal@mail.sysu.edu.cn |
| 推荐引用方式 GB/T 7714 | lssxal@mail.sysu.edu.cn,Fu, YG,Li, YX,et al. Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2012,4(6):352-361. |
| APA | lssxal@mail.sysu.edu.cn,Fu, YG,Li, YX,Sun, Y,&Xu, AL.(2012).Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies.JOURNAL OF MOLECULAR CELL BIOLOGY,4(6),352-361. |
| MLA | lssxal@mail.sysu.edu.cn,et al."Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies".JOURNAL OF MOLECULAR CELL BIOLOGY 4.6(2012):352-361. |
入库方式： OAI收割
来源：南海海洋研究所
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